In addition, there is increasing recognition that caspases
have numerous functions in addition to their roles as mediators of programmed cell death.
activation was detected using an enzyme-linked immunosorbent assay for cytokeratin-18 fragments, which are a byproduct of caspase
The role of caspases
in EAE was further supported by studies of mice that were deficient in the expression of caspase
are key enzymes that modulate and carry out the cellular signaling pathways involved in programmed cell death, also known as failure due to cell death.
His team created probes by affixing fluorescent "tags" to small molecules that were engineered to bind--and stay bound--almost exclusively to caspases
, and only when the caspases
are in an active state.
has built a leading technology platform in controlling caspase
activity and we
Idun has built a leading technology platform in controlling caspase
activity and we see potential broad application of this technology in treating liver damage associated with viral and non-viral diseases plus other areas of significant unmet medical need.
2+] exposure caused cell death, ROS generation, MMP loss, cyt c release, activation of caspases
, ERK activation, apoptosis, and finally auditory threshold shift.
When XIAP is left holding NO, the result is a double whammy for brain cells, since cells are programmed to self-destruct when either XIAP has NO attached to it or when caspases
Conclusion: The current study strongly reveals that rosamultic acid inhibits gastric cancer proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases
Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases
In a prospective study of 59 randomly selected patients with chronic hepatitis C virus (HCV) infection, a high degree of inflammatory liver injury on liver biopsy was associated with greater levels of the products that result from the cleavage of cytokeratin-18 (CK-18, a major intermediate filament protein in liver cells) by caspases
during apoptosis (Hepatology 2004;40:1078-87).
Seemingly aware of the danger they themselves pose, these abnormal cells often try to commit suicide by activating destructive enzymes called caspases
The research program is concentrating on caspases
3,6, and 7, the so-called "executioner caspases
are cellular proteases involved in processes such as apoptosis (cell death) and inflammation.