The Progen funded research team at the University of Queensland have demonstrated in preliminary studies that Progen's novel heparanase inhibitor, a carbohydrate based molecule, can reduce the thickening of the damaged cartoid artery by up to 45%.
In the experimental model of restenosis developed at the University of Queensland, the cartoid artery is damaged and the resulting alteration in the arterial muscle cells resembles that which occurs following angioplasty.