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Injured hearts that received the human cardiac muscle cell grafts showed partial re-muscularization of the scarred left ventricle.
Taken together, the results identify the cardionogen family members as important modulators of cardiac muscle cell development.
The discovery that the deformations produced by the beating cardiac muscle cells are important provides an entirely new perspective on the process," said Merryman, who directed the three-year study.
In fact, hematopoietic cells may not only follow their normal differentiation paths and generate blood cells, but they may also transdifferentiate into other types of tissue, including brain neurons, skeletal muscle cells, cardiac muscle cells and liver cells.
These new findings raise the possibility that statins can also recruit endogenous repair of cardiac muscle cells in some disease states.
Within the mammalian heart, the distribution of connexin43 (Cx43)-containing gap junctions is essential to facilitating the coordinated spread of electrical activation throughout the cardiac muscle cells (cardiomyocytes) and allowing the heart to contract properly.
While stem cell transplantation has been touted as a potential breakthrough treatment for heart attacks and other forms of heart disease, new research has found that stem cell injections can cause unexpected side effects and raises doubts about whether these so-called master cells can actually morph into cardiac muscle cells.
Xanthine oxidase inhibitors may improve myocardial work efficiency by sensitising cardiac muscle cells to calcium ions, which are a key determinant of cardiac muscle function.
Dystrophin plays an essential role in cell signaling and preserving the structural integrity of skeletal and cardiac muscle cells.
The study, conducted by Karolinska Institutet and Harvard University, shows that there was an effect on driving the formation of a small number of new cardiac muscle cells.
Summary: TEHRAN (FNA)- Using recent advances in marine biomechanics, materials science, and tissue engineering, a team of researchers has turned inanimate silicone and living cardiac muscle cells into a freely swimming "jellyfish.
Japanese researchers said Friday they have discovered stem cells in the heart that proliferate into cardiac muscle cells, a finding that may contribute to future medical treatment to regenerate damaged hearts.
Heart failure has been linked to abnormal calcium handling by cardiac muscle cells due to impaired activity of the SERCA2a pump.
Deepak Srivastava of the Gladstone Institutes and its affiliate, the University of California, San Francisco, said that this gene therapy approach resulted in new cardiac muscle cells that beat in synchrony with neighboring muscle cells and ultimately improved the pumping function of the heart.
They have succeeded in loading cardiac muscle cells onto a three-dimensional scaffold, created using the silk produced by a tropical silkworm.