Only the L-type channel is sensitive to calcium channel
The same relationships seen when NT-proBNP was measured at rest held true when the biomarker was measured at peak exercise or during recovery: Mean levels were significantly reduced compared with baseline if patients were on calcium channel
blockers for rate control, and significantly elevated above baseline while they were on beta-blockers.
By blocking calcium channels
in the muscle of the heart and blood vessels, calcium channel
blockers prevent calcium levels from building up in stimulated cells, leading to less contraction, increased blood vessel dilation, and decreased peripheral resistance.
Because of similarities in the amino acid sequences of the proteins that comprise channels for positively charged ions, scientists suspect that sodium and calcium channels
will prove to have the same basic structure as the KcsA channel.
Nevertheless, animals with either mutation show clear pathologic phenotypes, suggesting that compensatory changes in expression of calcium channel
subunits are limited in their ability to restore normal neuronal function.
Sever and his coworkers showed that the calcium channel
blocker-treated group had significantly less blood pressure variability over time than did those treated with atenolol.
The posters will highlight the company's non-toxic, selective T-type calcium channel
inhibitors for the treatment of brain and breast cancers.
Some 6 million Americans take any of the 10 calcium channel
blockers sold in this country, but only about 10 percent take the older versions.
Various forms of epilepsy, coordination disturbances (ataxias) and migraines are caused by mutations in the so-called P/Q-type calcium channel
that controls the influx of calcium ions into the nerve cells of the brain.
We are not sure why, but calcium channel
blockers may have natriuretic properties that are independent of so-called prostaglandin-dependent mechanisms within the kidney," he said.
Neuromed will use the funds to advance its lead program for developing calcium channel
blockers for chronic pain, as well as for its second major development program investigating calcium channel
blockers to treat pain, anxiety, epilepsy and cardiovascular diseases.
The guidelines point to a study of 557 patients with idiopathic PAH who underwent acute pulmonary vasodilator testing, with the 70 positive responders receiving long-term oral calcium channel
This Phase Ib study is the first step toward developing T-type calcium channel
blockers as a new class of compounds for the treatment of cancer," said Dr.
Use of calcium channel
blockers, one of the most widely prescribed classes of medications for high blood pressure and other ailments, has been tentatively linked to higher rates of cancer among older people in a federally financed study.
NASDAQ: ZLCS), a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain and immuno-inflammatory diseases, today announced that it is advancing Z160, its novel, first in class, oral, N-type calcium channel
blocker into multiple Phase 2a clinical trials for chronic pain indications.