whim

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Related to CXCR4: CCR5
  • noun

Synonyms for whim

Synonyms for whim

an impulsive, often illogical turn of mind

Synonyms for whim

a sudden desire

Related Words

an odd or fanciful or capricious idea

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References in periodicals archive ?
When scientists blocked CXCR4 from becoming activated or reduced cells' ability to make it, the mice were unable to restore myelin.
ASH 2009 Meeting Presentation: Clinical Oral presentation: TG-0054, a Novel and Potent Stem Cell Mobilizer, Displays Excellent PK/PD and Safety Profile in Phase 1 Trial Tuesday, December 8, 2009: 7:30 AM-9:00 AM Preclinical Poster: Rapid Mobilization of Murine Hematopoietic Stem and Progenitor Cells with TG-0054, a Novel CXCR4 Antagonist (Poster Board number: III-479) Monday, December 7, 2009: 6:00 PM-8:00 PM About TaiGen Biotechnology
These studies demonstrated Pepducin activity in the CXCR4 compounds that is equal or better than the current standard of care," commented Stephen Hunt, PhD, Sr.
In June 2008, optimization of Trofile made it substantially more sensitive at identifying very low levels of CXCR4 using virus (X4 or dual/mixed tropic) in HIV-1 patient samples while maintaining a high degree of accuracy.
Trofile is a clinically validated patient selection tropism assay that determines whether a patient is infected with a strain of HIV that uses either the CCR5 co-receptor (R5), the CXCR4 co-receptor (X4), or a combination of CCR5 and CXCR4 (D/M) to enter cells.
This study, Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells, describes a unique approach to the development of GPCR-targeted therapeutics using Anchor's proprietary pepducin technology.
Abstract #129 "T-Cells Edited to Express CCR5 or CXCR4 Fused to the C34 Peptide from gp41 Heptad Repeat-2 Exhibit Robust Protection from Diverse HIV-1 Isolates" Wednesday, March 6, 2013 The data demonstrate potent inhibition of HIV infection in cells expressing a chimeric protein comprising a portion of the HIV envelope fused to either the CXCR4 or CCR5 HIV co-receptors.
GMI's novel antagonists targeting E-selectin and CXCR4 were described in a presentation entitled "Novel Dual E-Selectin-CXCR4 Inhibitors Mobilize Human Acute Myeloid Leukemia (AML) Cells in the NODscid IL2Rc-/- Xenograft and Confer Susceptibility to Cytarabine.
SDF-1 binds with high affinity to the chemokine receptors CXCR4 and CXCR7.
PTX-9908 is an analog of Stromal Derived Factor -1 (SDF-1), a major chemotactic factor that plays a significant role in mediating cell trafficking via selective binding to CXCR4.
Using their novel approach, the scientists were able to disable a protein on the T-cell surface called CXCR4, which can be exploited by HIV when the virus infects T cells and causes AIDS.
In experiments in mice and human cells, researchers found that blocking CXCR4 -- a so-called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow -- halted disease progression in bone marrow and spleen tissue within two weeks.
The woman had been diagnosed as a child with WHIM syndrome, an immune disease caused by a mutation in a gene called CXCR4.
6] While most HIV-1 variants use CCR5 and CXCR4 as the main co-receptor in vivo, up to 12 other chemokine co-receptors (including CCR2b, CXCR6 and GPR1) for HIV infection have been identified in vitro.