inhibitor

(redirected from COX-2 inhibitors)
Also found in: Dictionary, Medical, Legal, Encyclopedia.
Related to COX-2 inhibitors: Prostaglandins
Graphic Thesaurus  🔍
Display ON
Animation ON
Legend
Synonym
Antonym
Related
  • noun

Antonyms for inhibitor

a substance that retards or stops an activity

References in periodicals archive ?
The selective COX-2 inhibitors are known to be associated with an increased risk of death in patients with previous MI.
The study included 23 traditional NSAIDs and four selective COX-2 inhibitors.
The results showed that of those currently using a COX-2 inhibitor, 19% were more likely to die after a stroke than those who didn't take the drug and new users of the medicines had a 42% increase in risk mortality from stroke compared to nonusers.
In so doing, researchers have identified several traditional herbs that contain natural and safe COX-2 inhibitors.
After its withdrawal in 2004, following the emergence of evidence of increased cardiovascular morbidity in the APPROVe (Adenomatous Polyp Prevention on Vioxx) study, COX-2 inhibitors represented less than 16% of the NSAID prescriptions.
Researchers noted the increase in fail-related injuries began in 2004, when the pain killer rofecoxib (Vioxx), a COX-2 inhibitor widely prescribed for arthritis pain, was taken off the market because of its link to a higher risk of heart attacks and strokes.
Compared with people who did not take the drugs, recent users were about 40% more likely to suffer irregular heart beat if they were on NSAIDs and 70% more likely if they were on COX-2 inhibitors.
The researchers found that use of NSAIDs or COX-2 inhibitors was associated with an increased risk of atrial fibrillation or flutter.
During the period spanned by our data (1999-2002), the two available COX-2 inhibitors were Vioxx and Celebrex.
Nonsteroidal antiinflammatory drugs (NSAIDs) are divided into two subcategories: (1) COX-2 specific inhibitors (referred to as COX-2 inhibitors for the remainder of this paper) such as celecoxib (Celebrex[R]), and (2) nonselective NSAIDs (referred to as NSAIDs for the remainder of this paper) such as ibuprofen (Motrin[R]).
The introduction of selective COX-2 inhibitors in the late 1990s substantially changed the arthritis treatment landscape because of the agents' ability to target the enzyme responsible for inflammation and pain while reducing the risk of NSAID-associated stomach complications, said Dr.
Available data do not allow for adjusted risk assessment for patients with preexisting renal disease on COX-2 inhibitors (strength of recommendation [SOR]: A, based on meta-analysis).
However, COX-2 inhibitors have been linked to a heightened risk of heart problems (SN: 10/30/04, p.
500) caution that 'there is now strong evidence to suggest that both the traditional NSAIDs (excluding aspirin) and the COX-2 inhibitors are associated with an increased risk of thrombotic events (including myocardial infarction and stroke) and excess mortality both in patients with and without pre-existing cardiovascular disease'.