Hypotension, profound sedation, coma, or respiratory depression may result if BELBUCA(TM) is used concomitantly with alcohol or other CNS depressants
(eg, sedatives, anxiolytics, hypnotics, neuroleptics, other opioids).
Concomitant administration with alcohol or other CNS depressants
can potentiate the CNS effects.
Combination with other CNS depressants
has an additive effect, increasing the risk of coma and death.
Concurrent use of oxymorphone hydrochloride extended-release tablets and other CNS depressants
including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol can increase the risk of respiratory depression, hypotension, profound sedation, or coma.
Caution must be used when administering Cesamet in combination with any CNS depressant
20-30% less), monitor patients for signs of sedation and respiratory depression, and consider using a lower dose of the concomitant CNS depressant
Lorazepam is a benzodiazepine with CNS depressant
, anxiolytic and sedative properties.
As with any benzodiazepine, physicians should caution patients about driving, operating machinery and the simultaneous ingestion of alcohol and other CNS depressant
Start with Butrans 5 mcg/hour patch, monitor patients for signs of sedation and respiratory depression, and consider using a lower dose of the concomitant CNS depressant
Potential serious adverse events caused by opioids include respiratory depression, potential for misuse and abuse, CNS depressant
effects, prolonged gastric obstruction, and severe hypotension.
Abuse of GHB, either alone or in combination with other CNS depressants
, is associated with CNS adverse reactions, including seizure, respiratory depression, decreases in the level of consciousness, coma, and death.
However, concomitant use of alprazolam, with other CNS depressants
such as alcohol and opioid analgesics, could have an additive CNS depression effect and lead to severe toxicity or even death.
It is extremely dangerous to self-administer nonprescribed benzodiazepines or other CNS depressants
while taking SUBOXONE Sublingual Film.