This study showed that CMV infection
was strongly associated with an age-related reduction in vital naive T-cells and accumulation of memory T-cells in the general population, but not in members of long-lived families.
Human CMV infection
is a strong candidate, being cholestatic in its own right.
Previous research has shown that dried blood spots could be used to identify CMV infection
More efforts should be directed towards recruitment of unpaid blood donors as a safer population of donors not only for CMV infection
but also for other infections.
Melnick et al (42,49) found CMV antigen and nucleic acid sequences in arterial smooth muscle cells, suggesting that CMV infection
of the arterial wall may be common in patients with severe atherosclerosis.
To address which assay is preferable, one must predetermine the purpose for which the assay is required: sensitive detection and monitoring of CMV infection
or identification of patients at risk of CMV disease.
A number of other blood tests can suggest a diagnosis of CMV infection
, but no blood test can reliably diagnose it.
Glioblastoma multiforme patients whose tumor specimen reveals immunohistochemical evidence of active CMV infection
, or whose blood test is CMV positive for active infection, should ask their oncologist to consider valganciclovir.
These include CMV infection
and disease in newborns, pregnant women, transplant patients, persons with HIV/AIDS, and other immunocompromised patients.
Human CMV infection
rates average between 50 percent and 85 percent of adults in the U.
Active significant CMV infection
is sometimes difficult to diagnose definitively in patients with advanced HIV disease because of its propensity to infect rapidly dividing cells and the frequent presence of other opportunistic infections.
Secondary endpoints included safety, time to CMV disease, time to CMV infection
, acute rejection, and graft loss.
This strongly suggests that the CMV infection
and the high-cholesterol diet might be working together to cause atherosclerosis," said Crumpacker.
Twelve kidney patients (20%) and 4 liver patients (13%) presented with antigens in the blood and/or symptoms of CMV infection
, all within 6 months of transplantation.
Other signs and symptoms of fetal CMV infection
include intrauterine growth retardation, jaundice, petechiae, hepatosplenomegaly, and microencephaly.