CFTR


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Related to CFTR: cystic fibrosis, CFTRI
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  • noun

Synonyms for CFTR

the gene that is mutated in cystic fibrosis

References in periodicals archive ?
The results suggest growing nasospheroids from nasal samples could provide a quick screening method to determine how a patient's cells react to different CFTR drugs.
The CFTR activators and inhibitors was developed in the UCSF laboratory of Alan S.
It could be that a variant in another gene counteracts that specific mutation in the CFTR gene.
CFTR dysfunction in the lungs results in thick pulmonary secretions as the aqueous surface layer (ASL) lining the alveolar epithelium becomes dehydrated and creates a prime environment for the development of chronic infection.
achieves this by preventing the faulty CFTR protein from being degraded before it is successfully transported to the cell membrane.
The CFTR is a kind of Cl[sup]− channel in epithelial membrane regulated by phosphorylation, which is located primarily in the airway epithelial cells of apical membrane [Figure 1].
The CFTR mutations that cause CF vary in different ethnic groups, and the Venezuelan population contains a mix of different ethnicities (13, 14).
However, when a CFTR gene mutation is detected, there is an increased risk of cystic fibrosis in the child.
We describe a proof-of-concept study to show the efficacy in the clinical laboratory of detecting different classes of mutations in the CFTR coding sequence.
Gradual progress is being made in emerging protein repair and gene therapy, both of which aim to develop therapeutic strategies which target specific CFTR mutations, in order to improve or restore CFTR function.
CF is caused by a defective or missing CFTR protein resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Not only does latonduine A get CFTR to the surface in cell-based assays, it also provides up to 9 per cent correction in mouse models of cystic fibrosis.
A mutated CFTR is responsible for the genetic disease cystic fibrosis.
CFTR proteins regulate the flow of salt and water across the cells.