The study focused on telomere length as a marker of replicative aging in CD8 cells
, a subset of immune cells known as cytotoxic T-cells which kill virus-infected cells.
17,18) He cites one of his own studies to note that up to half of peripheral CD8 cells
remain on active patrol during untreated HIV infection (versus fewer than 10% in people without HIV) and that antiretroviral therapy does not completely halt this systemic hopscotch, at least not in the first years of therapy.
In addition to a rapid onset of effect, T cell expansion was sustained with IL-7, all patients having an improvement from baseline in their CD4 and CD8 cell
counts at Week 48.
SAN FRANCISCO -- A randomized trial of smoked marijuana and dronabinol in HIV-positive patients revealed significant weight gain in both experimental groups and significant increases in CD8 cell
counts in the marijuana group.
A CD8 cell
can directly kill a target through the elaboration of different molecules, or it can indirectly suppress virus either through the chemokines or other factors that block virus.
While most scientists have focused on the declining number of CD4 cells that follows untreated HIV infection, others have documented that CD8 cell
counts also fall over time, especially late in an infection.
In addition, no spikes in viral load, significant changes in CD4 or CD8 cell
counts, or manifestations of autoimmunity were observed during or after injections.
This indicates that Multikine treatment shifts the immune response from a mainly CD8 cell
anti-tumor response to a predominately CD4 anti-tumor response.
The Stanford team found similar numbers of CD8 cells
in the two groups.
Effros and colleagues demonstrated that introducing the telomerase gene into CD8 cells
from HIV/AIDS donors increased: 1) their proliferative capacity, 2) their ability to produce IFN-gamma, and 3) their ability to inhibit virus production and kill HIV-infected T-cells.
The data show that the vaccine initiates the response through CD8 cells
, but CD4 cells and interferon gamma play a more important role in delivering the actual protection to virus challenge.
Normally, these CD8 cells
kill other cells and make interferon gamma, a TH1 messenger.
Mike Watts of the Hematology Department at University College London Hospital described the performance of the Eligix(TM) TCell Separation System to deplete CD8 cells
from Donor Leukocyte Infusion (DLI).
Researchers concluded that CD8 cells
may play a protective role in these mice by suppressing the CD4 cells, which attack pancreatic islet cells (SN:3/31/90, p.
When they injected prediabetic mice with CD8 cells
and with spleen cells known to accelerate diabetes onset, the mice did not develop the disease.