A study of NK cell function in a cohort of ECs demonstrated only limited and less effective HIV-1 inhibitory capacity in vitro compared with CD8 T-cells
First, they exposed the CD8 T-cells
from HIV-infected persons to TAT2 to see if the chemical not only slowed the shortening of the telomeres but also improved the cells'' production of soluble factors called chemokines and cytokines, which had been previously shown to inhibit HIV replication.
In addition to providing further evidence of the ability of IL-7 to stimulate the expansion of CD4 and CD8 T-cells
in peripheral blood, the results demonstrate the importance of IL-7 in stimulating T-cell repopulation of the lymphoid tissue layer in the mucous membrane of the GI tract.
Research shows that the presence of cytotoxic CD8 T-cells
are correlated with response to cancer immunotherapy.
By removing and sorting through immune-system cells called CD8 T-cells
from AIDS patients, they plan to single out and then in the lab greatly boost the number of such cells that recognize HIV When returned to the patient, these billion extra cells should help the body stem HIV infection by recognizing and destroying any cells containing the virus, Greenberg says.
Clinical trials including more than 220 patients in Europe, North America, South Africa and Taiwan have demonstrated the potential of IL-7 to expand and protect CD4 and CD8 T-cells
Cytotoxic T-cells, also referred to as CD8 T-cells
, are required to target and eliminate pathogen-infected or cancerous cells.
By using modified, non-natural peptides that stimulate both CD4 and CD8 T-cells
, INNO-305 may offer an advantage over other WT1 peptide immunotherapy approaches.
During the experiments, Gwendolyn Binder, a graduate student, observed that, using interferon-[gamma], CD4 and CD8 T-cells
both successfully cleared the virus in the neurons from the spinal cord and brain stem.
On September 26 scientists at the Aaron Diamond AIDS Research Center (ADARC) announced that they had identified a significant contributor to a long-sought antiviral factor, secreted by certain CD8 T-cells
, that inhibits HIV replication.
Prior research has demonstrated that CD4 and CD8 T cells are both important in cellular immune responses; however, CD8 T-cells
, or killer T cells, are considered especially integral to fighting cancers and chronic infectious diseases.
In addition, a reduction in the viral reservoir, as measured by integrated HIV DNA in sorted CD4 cells, correlated with increased numbers of functional HIV gag-responsive CD8 T-cells
, suggesting that these cells can mount an anti-HIV response with the help of ZFN modified CD4 T-cells (SB-728-T).
Next-generation HIV vaccine achieves seven-fold increase (7% to 52%) in response rate of CD8 T-cells
when delivered with electroporation; robust CD4 or CD8 T-cell
responses observed in 89% of subjects
TAT0002 was previously shown to stimulate the production of IFN-gamma -- a molecule involved in the anti-viral response of cytotoxic CD8 T-cells
specific for the HIV-1 AIDS virus -- and to enhance the ability of the CD8 cells to proliferate and kill HIV-1-infected CD4 cells.
In Cohort 3* increased levels of CCR5 modified CD8 T-cells
were observed post infusion, suggesting expansion of CD8 T-cells