cytotoxic T cell

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Related to CD8+ T cells: lymphocyte activation
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Synonyms for cytotoxic T cell

T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it

References in periodicals archive ?
Overall, our studies suggest that an influenza vaccine capable of eliciting both CD8+ T cells and antibodies specific for highly conserved influenza proteins may be able to provide protection in humans, and act as the basis for a potential 'universal' vaccine," says Wherry.
The distribution of CD38 expression on CD8+ T cells is continuous and does not show clearly defined negative or positive populations in either healthy or HIV-1-infected individuals, nor does it follow a Gaussian distribution when defined by isotype controls [78].
Additionally there was an increase in the cytolytic activity of CD8+ T cells.
After intranasal infection, priming, activation, and expansion of naive influenza-specific CD8+ T cells occur in the draining mediastinal lymph node 3-4 days after infection (12,13).
Non-progressors'' - people who fail to get Aids - had CD8+ T cells that were better able to divide and proliferate when called into action against HIV.
We describe here a new generation Capcellia CD4/CD8 immunoassay method (Whole Blood Capcellia CD4/CD8) that provides a direct determination of CD4+ and CD8+ T cells in whole blood without requiring the preparation of peripheral blood mononuclear cell suspensions.
The highest CMV-specific response levels were noted in this patient with a history of CMV viremia and low-level CMV-specific CD8+ T cells prior to rhIL-7 (5.
In this phase I study, Inovio's HIV immunotherapy, which had been previously tested only in disease prevention, drove the expansion of activated HIV-specific CD8+ T cells with functional characteristics similar to those of long-term non-progressors.
Research objectives and content T lymphocytes can differentiate in the thymus from common precursor cells, into one of two phenotypically distinct lineages, called CD4+ or CD8+ T cells.
CD8+ T cells ("killer T cells"), on the other hand, normally attack and destroy only infected cells.
IL-4, IL-5, IL-10 and high levels of CD38 and HLA-DR expression amongst CD4+ and CD8+ T cells [10-12].
Data from three separate study sites showed that results obtained using the Guava EasyCD4(TM) and EasyCD8(TM) Assays for the enumeration of Human CD4+ T cells and CD8+ T cells showed excellent correlation with the standard, clinically approved BD MultiTEST(TM) (flow cytometry) assay.
Immunologic activity was assessed by changes in proliferative capacity of HIV-specific CD8+ T cells and confirmed that AGS-004 was immunogenic in the majority of subjects.
Cantor and his team reported that not just CD4+T cells but CD8+ T cells as well include a subset that helps dampen the immune response.