The goal of anti-retroviral therapy (ART) in HIV is to bring down the viral load and increase the CD4 cell
count so that the body reconstitutes its immune system AND increases the CD4 count to a manageable level of 500 and more.
Increasing virulence of the virus was suggested by an annual fall in CD4 cell
count of approximately 5 [cells/mm.
The SMART trial enrolled 5,472 HIV-positive adults with CD4 cell
counts of at least 350 cells/[mm.
Also, they recorded a higher parasitaemia compared to those with CD4 higher than 200 cells/[micro]l, this possibly could be due to the fact that the CD4 cells
which play a central role in the immune defence against many pathogens have been depleted by the HIV virus.
In the phase I, open-label clinical trial, five highly active antiretroviral therapy-resistant patients with CD4-cell counts between 200 and 500 cells/[micro]L were serially enrolled to receive about 10 billion modified autologous CD4 cells
in a single dose.
Researchers eventually learned that people with the Delta 32 mutation lack a functional gene coding for producing a receptor called CCR5--one of two chemical "locks" on the surface of CD4 cells
that HIV can penetrate.
Doctors can track the progress of HIV infection by measuring the number of CD4 cells
in the blood.
The proportion of CD4 cells
normally exceeds that of CD8 cells.
The current theory is that HIV exhausts the immune system, making the body more susceptible to other infections that lead to AIDS, by constantly killing off its supply of certain disease-fighting cells known as CD4 cells
Patients switching from 3TC to ATC improved their response, with the percentage of patients with viral loads below detectable and the levels of CD4 cells
both increasing after the switch to ATC at week 24
At the time of HIV infection a massive loss of CD4 cells
Because patients may have HIV-1 that exclusively uses CX chemokine receptor 4 (CXCR4) or both CXCR4 and CCR5 to gain entry into CD4 cells
, clinicians must determine what mix of receptors are represented in a patient's viral load before prescribing maraviroc.
That research has suggested that the connection might be through the CCR5 receptor, the major coreceptor of HIV on CD4 cells
If patients are on the cusp but defer starting treatment, then CD4 cells
must be measured every 3 months.
are a key part of your body's disease-fighting defenses, called the immune system.