Now there's hope that people may be able to increase their mass of brown adipose tissue
We plan to further investigate the actions of Tyk2 and Stat3 in order to better understand the mechanisms involved in the development of brown adipose tissue
But our findings showed that treating mice with Bmp8b did not have this effect, it simply made them lose weight by burning more fat in their brown adipose tissue
The compounds selectively modulate mitochondrial control of certain metabolic-signaling and nutrient-sensing pathways resulting in improved insulin action and generation of brown adipose tissue
without fluid retention or weight gain.
The scientists believe that the deletion of the DOR gene in mice stimulated the expression of other genes in brown adipose tissue
that promoted thermogenesis.
June 21, 2011 /PRNewswire/ -- Metabolic Solutions Development Company (MSDC) and collaborators will present their research providing insights into the therapeutic potential of increasing brown adipose tissue
in the treatment of diabetes and the unique mechanism of action of the company's novel insulin sensitizers that connects with pathways known to be dysregulated in diabetes at the American Diabetes Association's (ADA) 71st annual Scientific Sessions conference in San Diego, Calif.
Brown adipose tissue
(brown fat) is metabolically active.
Brown adipose tissue
(often known as brown fat) is a specialized tissue that burns calories to generate body heat in rodents and newborn humans.
The FDA also recommended that the Company conduct a two-year rodent study of Invicorp(TM) as a result of previously reported brown adipose tissue
proliferations observed in the course of a competitor's rodent study in which phentolamine mesylate, an ingredient formulated in low concentrations in Senetek's Invicorp(TM) product, was administered daily.
We have always believed that there has been a link between the regulation of thermogenesis (heat production) and weight modulation in people, but could not identify the molecular mechanisms involved because there are very small amounts of UCP and brown adipose tissue
present in humans," said Dr.
The articles are titled "Estrogen Signaling via Estrogen Receptor Beta" and "Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue
This research has shown that Brown Adipose Tissue
is the organ in the body which has the sole purpose of burning excess calories and fat.
However, it's still unclear whether the findings in mice are translatable to humans, because one of the tissues that mediates the thermogenic response is brown adipose tissue
, a type of fat uncommon in adult humans.