Fentanyl buccal tablet for the treatment of breakthrough pain
in opioid-tolerant patients with chronic cancer pain.
The CIPCEA and PCEABI groups did not differ significantly in the incidence of breakthrough pain
For increases in the dose of daily opioid, adjustments can be made by adding the total amount of rescue medication (needed for breakthrough pain
over a 24-hour period) to the ATC dose to calculate the new daily dose of opioid.
Robert Shibuya, a medical officer in the division of anesthesia, analgesics, and rheumatology products at the agency, said that based on a preliminary review of safety and efficacy data from the company, the agency agreed that Fentora was effective over 12 weeks for breakthrough pain
in patients without cancer, but that the evidence of more abuse-related serious adverse events raised public health concerns.
However, he still has significant pain upon arising every morning, and because he is more active around the house, finds that he needs the 2 extra doses of hydrocodone for breakthrough pain
Cephalon said it expects to seek regulatory approval for an expansion of the labeled indications for FENTORA, which will include data from Phase 3 studies in patients with chronic pain conditions associated with breakthrough pain
, such as neuropathic and low back pain.
Mantyh predicts that OPG will work against both background and breakthrough pain
In Japan, approximately 455,800 cancer patients had breakthrough pain
in 2011, but the number is expected to increase to approximately 536,700 by the end of 2021.
According to Orexo AB, Abstral is a novel, rapidly-disintegrating, sublingual (under the tongue) rapid acting formulation of fentanyl, a well-established opioid, and is indicated for the management of breakthrough pain
Consensus panel recommendations for the assessment and management of breakthrough pain
including breakthrough pain
, can be managed and should be addressed as part of your overall cancer care.
WASHINGTON -- Adding epinephrine to epidural bupivacaine and fentanyl significantly reduced the breakthrough pain
of women in labor, based on supplemental pain relief data from a randomized study of 107 women with uncomplicated singleton pregnancies.
Abstral's formulation is based on Orexo's unique sublingual tablet technology in which a rapidly dissolving tablet is placed under the tongue and the active substance is absorbed by the mucous membrane, resulting in very rapid pain relief for patients suffering from breakthrough pain
The following information was recorded: parturients' demographic data, loss of resistance technique used, type and amount of local anaesthetic solution administered, complications encountered during procedure, pre-block and post-block pain scores, incidence of breakthrough pain
requiring supplemental medication and post-block side-effects.
Of 197 patients who used the tablets for up to a year, 80% said they preferred them to the pain medication they took previously for breakthrough pain
, said Dr.