The movement of preleptotene/ leptotene spermatocytes across the blood-testis barrier
(BTB), also known as the Sertoli cell barrier, during the seminiferous epithelial cycle is one of the most important cellular events taking place in the mammalian testis.
Dym M, Fawcett DW (1970) The blood-testis barrier
in the rat and the physiological compartmentation of the seminiferous epithelium.
Cytokines, polarity proteins, and endosomal protein trafficking and signaling--The Sertoli cell blood-testis barrier
system in vitro as a study model," Methods in Enzymology 534: 181-194.
Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier
dynamics," Proceedings of the National Academy of Sciences of the United States of America 106(25): 10213-10218.
TGF-[beta]3 and TNF[alpha]perturb blood-testis barrier
(BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis," Developmental Biology 327(1): 48-61.
An orchiectomy, especially in early-stage disease, is advantageous because it provides tissue for pathologic evaluation and removes a sanctuary site, as the blood-testis barrier
makes testicular tumors inaccessible to systemic chemotherapy.
Regulation of blood-testis barrier
dynamics: an in vivo study.
These cells are joined laterally by tight junctions to form the blood-testis barrier
The blood-testis barrier
forms an impermeable lining around the inside of the tubule and protects vulnerable growing sperm from infections, toxins and immune system cells.
Demonstration of a functional blood-testis barrier
By now, it is common knowledge among researchers that ABC transporters play a key role in the function of the blood-brain barrier (BBB), blood-CSF barrier, blood-testis barrier
, intestinal epithelia (absorption), airway epithelia, liver epithelia and the kidney epithelia," explained Gabor Heltovics, SOLVO's business development director.
The blood-testis barrier
was found to have normal organization between the basal and adluminal compartments of the seminiferous tubules.
Cadmium chloride does not cause significant damages in the testes at a low dose of less than 3 mg/kg; however, it induces mild apoptosis of germ cells and damage to blood-testis barrier
(BTB) (12, 13).
Rictor/mTORC2 regulates blood-testis barrier
dynamics via its effects on gap junction communications and actin filament network," FASEB Journal 27(3): 1137-1152.
Effects of daily dermal application of DEET and permethrin alone and in combination, on sesorimotor performance, blood-brain barrier, and blood-testis barrier