involves transport of the unconjugated insoluble form (bound to albumin) to the hepatocyte where conjugation occurs, increasing its solubility.
To provide a better understanding of the pathophysiology of hyperbilirubinemia, education addressed bilirubin metabolism
and the causes, risk factors, consequences, and treatment of hyperbilirubinemia.
GILBERT'S SYNDROME is a common benign hereditary disorder of bilirubin metabolism
with a prevalence of 3% to 6% in the general population.
We believe CoSense has potential applications in the monitoring of a range of diseases involving hemolysis and altered bilirubin metabolism
and we appreciate being able to share these important findings with the hematology community at ASH this year.
Therefore, the genes involved in bilirubin metabolism
as well as red blood cell life span, such as G6PD (glucose-6-phosphate dehydrogenase), are important candidate genes for the control of serum bilirubin concentrations.
Activation of heme oxygenase and the heme catabolic pathway are both strongly influenced by genetics and have been proposed to have beneficial effects on diseases by protecting against oxidative stress, possibly through the action of bilirubin or in conjunction with bilirubin metabolism
7] allele nor have other UGT1A1 genetic deficits points toward the existence of other inherited or acquired factors affecting bilirubin metabolism