bile acid

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  • noun

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any of the steroid acids generated in the liver and stored with bile

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Curiously, about 15 grams of bile salts are excreted into the intestine each day, yet the human body contains only about five grams in total.
The toxic effects of elevated levels of bile salt and bilirubin in the cell cause local damage, while the released mediators result in systemic complications (1).
3% bile salt concentrations was prepared and inoculated with 1 mL of active cultures of each isolate.
The ability of KCC-32 to grow in GI tract conditions like low pH, resistant to bile salts was analyzed.
Researchers have completed field trials of the robot which can navigate difficult reefs, detect the starfish and deliver a fatal dose of bile salts, autonomously and precisely.
Consequently, accumulation of toxic hydrophobic bile salts within hepatocytes may cause hepatocyte toxicity, liver failure, immunodeficiency, coagulation disorders, renal failure, impaired wound healing, and sepsis [18-20].
And rather than esophagitis due to GERD being a top-down process, from surface epithelium to submucosa, multiple lines of evidence now suggest it is a bottom-up phenomenon sparked by activation of a hypoxia-inducible factor that occurs when esophageal epithelium is exposed to acidic bile salts, Rhonda Souza, MD, said at the meeting sponsored by the American Gastroenterological Association.
The difference (d) in the length of time between the two samples was considered to be the delay in growth due to inhibition by the bile salts.
Preliminary studies of HIF-2a inhibition in esophageal squamous cells in culture exposed to acidic bile salts show promising results as a potential therapeutic strategy to reduce proinflammatory cytokine expression.
These bile salts are subsequently degraded to potentially carcinogenic secondary bile salts, by colonic bacteria4.
The bile salts break up and coat the fat to form much finer droplets.
Regurgitation of duodenal contents, including alkaline pancreatic-duodenal secretions, bile salts, and lysolecithin into the gastric cavity may disrupt the gastric mucosa barrier and damage the mucosa epithelium.