Conclusion: Hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmias can be well treated with low-dose amiodarone and Betaloc, with mitigated symptoms, improved prognosis and few adverse reactions.
5 Therefore, we herein aimed to study the effects of low-dose amiodarone in combination with Betaloc on hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmias.
Treatment Methods: The treatment group was orally administered with low-dose amiodarone and Betaloc ; Amiodarone: 0.
The control group was only administered with Betaloc at the same dose.
Betaloc effectively stabilizes ventricular rate by binding b1 adrenergic receptor, exerting antagonistic effects on its excitation, suppressing sympathetic excitement, decreasing the phase-4 depolarization rate and phase-0 action potential rising rate of cardiomyocytes, as well as reducing their self-regulation and conduction rate.