Modern strains of MRSA have become broadly resistant to antibiotics, including beta-lactam antibiotics
, such as penicillins.
32) Phenotypically, the strains were resistant to the beta-lactam antibiotics
, but much more susceptible to other antibiotic classes than hospital-acquired MRSA (HA-MRSA).
NYSE MKT: SYN), this week presented initial data that support the Company's development of a platform of therapeutics designed to protect the microbiome from carbapenems, a class of beta-lactam antibiotics
Unlike hospital strains, which typically are resistant to multiple antibiotics and can be shown by typing schemes to be related to other hospital strains, these so-called community strains have tended to be susceptible to other antibiotic classes and often are resistant only to beta-lactam antibiotics
When used in combination with a therapeutically relevant dose of a beta-lactam antibiotic
, either a penicillin or a cephalosporin, these compounds have demonstrated in vivo to successfully treat animals with antibiotic resistant infections.
A two-component drug containing an AlamX inhibitor and a beta-lactam antibiotic
has the potential to treat a broad spectrum of microorganisms for which no effective therapies exist.
are a mainstay in hospital infection management and include the commonly used penicillin and cephalosporin classes of antibiotics.
difficile) infection (CDI), antibiotic-associated diarrhea (AAD) and secondary antibiotic-resistant infections in patients receiving intravenous (IV) beta-lactam antibiotic
difficile) infection (CDI), antibiotic-associated diarrhea (AAD) and secondary infections with healthcare-acquired, drug-resistant pathogens in patients receiving intravenous (IV) beta-lactam antibiotic
Hospira's acquisition of the Orchid API facility will support supply continuity of key beta-lactam antibiotic
products, improve our cost position and pave the way for future API development," said Dr.
NYSE MKT: SYN), a clinical stage company focused on developing therapeutics to protect the gut microbiome while targeting pathogen specific diseases, announced positive topline results from the first Phase 2a study of SYN-004, the Company's candidate designed to protect the gut microbiome from the unintended effects of certain commonly used intravenous (IV) beta-lactam antibiotics
for the prevention C.
Like most carbapenemases, KPCs are enzymes which inactivate all beta-lactam antibiotics
, including carbapenems, penicillins, cephalosporins and monobactams.
Analysis of twelve beta-lactam antibiotics
in human plasma by HPLC with ultraviolet detection.
00; Lot 2 - antibiotics (Other beta-lactam antibiotics
third generation cephalosporins, other beta-lactam antibiotics
cephalosporins fourth generation) - 21.
and Enterome Bioscience SA have entered into an agreement to conduct metagenomic research on the effects of beta-lactam antibiotics
on the gastrointestinal microflora (microbiome) of human patients.