6) Although the US hantaviruses cause HPS and not HFRS like the Old World hantaviruses, both of the Southeastern hantaviruses, Bayou virus
, and Black Creek Canal virus may cause HPS associated with clinical findings similar to Eurasian strain-caused HFRS, including severe myositis, renal insufficiency with elevated creatinine and blood urea nitrogen (BUN) levels, and intra-alveolar hemorrhage.
Our focus was on Bayou virus
(BAYV) and its primary host, Oryzomys palustris, which has been linked to Hantavirus Pulmonary Syndrome in the southern U.
Sin Nombre virus--the most common pathogen responsible for hantavirus in the United States--accounted for the infections in 32 participants; the other patient was infected with Bayou virus
The viruses known to cause HPS on the North American continent are Bayou virus
, Black Creek Canal virus (BCCV), Choclo virus (CHOV), New York virus, and Sin Nombre virus (SNV) (3-7).
Other HPS-associated viruses include New York and Monongahela viruses (mice of the genus Peromyscus are reservoirs), associated with HPS in the eastern United States (7-9), Bayou virus
, found in the southeastern United States (Oligoryzomys palustris rice rats are reservoirs) (10-12), and Black Creek Canal virus (Sigmodon hispidus cotton rats are reservoirs), which was associated with 1 case of HPS in Florida (13,14).