Angelina Jolie famously revealed she had a double mastectomy after discovering she carried the BRCA1 gene
Caption: All four of the rare aggressive uterine cancers occurred in the 296 women who had BRCA1 gene
CUTLINE: (PHOTOS) Jilliane Sotelo, above, a genetic counselor at UMass Memorial Medical Center in Worcester, has had more requests for consultations since actress Angelina Jolie disclosed in May that she had a double mastectomy because she carried the BRCA1 gene
mutation, which increased her risk for breast cancer.
Testing showed mum-of-six Angelina, 37, had the BRCA1 gene
, which indicates a higher risk of breast cancer.
Having being told that she carried the BRCA1 gene
she decided she wasn't going to wait for cancer to strike.
The A-list actress revealed that she was forced to make the agonising decision to have a preventative surgery, after tests showed she had the BRCA1 gene
- which meant she had an 87 per cent chance of contracting cancer.
It is also associated with mutations in the BRCA1 gene
that indicate a greatly increased risk of breast cancer.
The treatment was successful, but further examination revealed Luan was carrying the BRCA1 gene
- the main trigger for the disease.
The researchers deleted the BRCA1 gene
in both mouse basal stem cells and luminal intermediate cells.
In 2008, Angela had a genetic test and the results came back in July 2009 to show that she had inherited a faulty BRCA1 gene
The identification of the BRCA1 and BRCA1 gene
sequences is unquestionably a valuable scientific achievement for which Myriad deserves recognition, but that is not the same as concluding that it is something for which they are entitled to a patent," Sweet concluded in his judgment.
In a new study in mice, scientists have compensated for mutations in the Brca1 gene
that can lead to cancer by deleting a second gene, which then lessens the probability of cancer.
To our knowledge, this report is the first of nonpathogenic ASS occurring in the BRCA1 gene
The baby grew from an embryo screened to ensure it did not contain the faulty BRCA1 gene
, which passes the risk of breast cancer down generations.
While a first in Britain, the strategy has been used elsewhere across the world to screen for the cancer-related BRCA1 gene
variant, and the technique has also been previously applied by British doctors to avoid the transmission of other cancers and diseases.