Morphologically activated B-lymphocytes
are lymphoplasmacytoid cells and plasma cells (2).
LymphoStat-B is a human monoclonal antibody that specifically recognizes and inhibits the biological activity of B-lymphocyte
stimulator, or BLyS.
Phytohemagglutinin (PHA, Siga) was used as T-lymphocyte mitogen and lipopolysaccharide (LPS, Escherichia coli 055:B5, Siga) as a B-lymphocyte
deficiency may have been a consequence of treatment with immunosuppressive agents, or defective T- and B-cell interactions.
T cells kill cells infected with viruses, arm phagocytic cells to better kill certain bacteria and fungi; and regulate the production of antibody B-Lymphocyte
suppression in multiple myeloma is a reversible phenomenon specific to normal B-cell progenitors and plasma cell precursors.
The protein, which goes by several names including B-lymphocyte
stimulator (BlyS), boosts antibody production by triggering the growth and activity of B cells (SN: 8/21/99, p.
The fact that 2 baboon B-lymphocyte
cell lines were permissive for infection is particularly important, according to the investigators.
The Epstein-Barr virus (EB), which brings about infectious mononucleosis, takes up residence in the B-lymphocyte
cells of the immune system.
Two new B-lymphocyte
stimulator (BLyS) candidates have emerged within the late-stage SLE pipeline.
A drug that inhibits early-stage B-lymphocyte
activation reduced disease activity in patients with relapsing-remitting multiple sclerosis, and showed potential to significantly decrease the annual number of new brain lesions.
Blisibimod targets elevated levels of B-lymphocyte
stimulator (BAFF), which have been associated with a variety of B-cell mediated autoimmune diseases, including systemic lupus erythematosus (lupus) and rheumatoid arthritis.
Mean counts and percentages of all T- and B-lymphocyte
subsets increased after 3 days of illness compared with results obtained during the first 3 days of illness (Figure 1).
Expression of the B-lymphocyte
marker CD19 and activation marker HLA-DR were significantly higher in CB than in MPB (p=0.
Immunization that results in an IgG autoantibody response requires switching of B-lymphocyte
class, and therefore CD4 T cells must be involved in addition to naive mature B cells.