In the absence of the AB challenge, tau reduction had no effect on axonal transport.
Whether tau affects axonal transport or not has been a controversial issue, and nobody knew how to prevent AB from impairing this important function of neurons.
Reference Study Bodian and Howe 1941 Olfactory axonal transport
of polio virus (30 nm) after intranasal instillation in chimpanzee; transport velocity, 2.
Sirus' Axonal Transport technology allows drugs to be delivered intracellularly to the cell body of the neuron through anatomically targeted intramuscular injection, and is likely to be of use for the treatment of neuropathic pain associated with a number of inadequately treated central and peripheral nervous conditions, such as trigeminal neuralgia and diabetic neuropathy.
These products are underpinned by Sirus' three proprietary drug delivery technologies, namely axonal transport, controlled kinetic polymers and sublingual (under the tongue) targeting and delivery systems.
Paper LSThB3, "Single Molecule Imaging of Axonal Transport
in Live Neurons," is at 9 a.
The funding, awarded under the Foundation's Therapeutics Development Initiative, enables KineMed to assess if its proprietary biomarker measurements of microtubule function (MT) and axonal transport
can be applied to people that it pioneered in pre-clinical animal models of PD.
One of the proteins most strongly implicated in the pathology of Alzheimer disease (AD), the tau protein, is a normal part of the axonal transport mechanism (Eva-Maria Mandelkow, Max-Planck Unit for Structural Molecular Biology, DESY, Hamburg, Germany).
Failure of axonal transport is beginning to be seen as a central feature of neurodegenerative diseases, and further study of the pathophysiological mechanisms involved should lead to a better understanding of the causes of neurodegeneration, and new methods of treatment (William Mobley, Stanford University School of Medicine, Stanford, USA).
and neurotransmitter release, for example, are now known to occur by mechanisms that are related to those of membrane trafficking and secretion used by all eukaryotic cells, and the neurofilaments whose unusual staining properties allowed neuroanatomists to trace axonal tracts are now recognized as part of a larger family of intermediate filaments found in many cell types.