MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport
in iPSC-derived dopamine neurons.
The GTPase dMiro is required for axonal transport
of mitochondria to Drosophila synapses," Neuron, vol.
On the other hand, in previous studies we have shown that the HRP axonal transport
of Pc motoneurons is influenced by PVN oxytocin, (15) therefore, stimulated pelvic nerve could increase the discharge of this peptide, or any other brain transmitter that is normally released on motoneurons, and the stimulated nerve also could activate both dorsal and motor roots, besides of the supraspinal circuits.
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport
Small quantities of botulinum toxin can undergo retrograde axonal transport
to the central nervous system, but there is no evidence that this has any effect on humans.
Retrograde axonal transport
of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult.
Subcellular structure, axonal transport
mechanisms and the structural basis of electrical and chemical signalling are described concisely.
Other mechanisms that have been implied in ALS, such as excitotoxicity and defective axonal transport
, may be consequences of oxidative stress .
The transport of the administered drug into extradural or subarachnoid space either by diffusion or by the centripetal axonal transport
results in central action.
sup], However, the technique of retrograde labeling has a limitation that retrograde-labeling of RGCs depends on active axonal transport
, a cellular function which is thought to be compromised under the incidence of elevated IOP.
6,7) Listerial rhombencephalitis is thought to occur through a unique mechanism of infection through injured oral mucosa with retrograde axonal transport
along cranial nerves.
AB proteins, which build up to toxic levels in the brains of people with AD, impair the axonal transport
of these cargoes like mitochondria.
APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport
of both vesicles and mitochondria in Drosophila.
For example, nanosized ferritin and iron-dextran, after injection into the tongue of mice, labeled the neurons of the hypoglossal nuclei, and injection of both of these NSPs into facial muscles of mice also resulted in synaptic uptake; cationized ferritin was also detected in cell bodies of facial neurons, indicating that electrical charge is of importance for incorporation into axons and axonal transport
(Arvidson 1994; Malmgren et al.
working with collaborators at the University of California San Francisco and the University of Osnabruck, Germany, used the (2)H2O labeling approach to specifically track, for the first time, the movement of cargo proteins that rely on axonal transport
prior to release into the cerebrospinal fluid (CSF).