High-dose therapy with single autologous transplantation
versus chemotherapy for newly diagnosed multiple myeloma: A systematic review and meta-analysis of randomized controlled trials.
NEW YORK & PETACH TIKVA, Israel -- BrainStorm Cell Therapeutics (OTC:BCLI) announced today that it has completed the planned interim safety review of its Phase I/II ALS (Amyotrophic Lateral Sclerosis) clinical trial, indicating that autologous transplantation
of the Company's cell therapy was well-tolerated, appears to be safe for use, and did not present any undue risks to the study participants.
The use of umbilical cord blood as a source of hematopoietic stem cells for allogeneic and autologous transplantation
has increased markedly over the last 30 years.
Ljungman P, Bregni M, Brune M, Cornelissen J, de Wine T, Dini G, Einsele H, Gaspar HB, Gratwohl A, Passweg J, Peters C, Rocha V, Saccardi R, Schouten H, Sureda A, Tichelli A, Velardi A, Niederwieser D; European Group for Blood and Marrow Transplantation: Allogeneic and autologous transplantation
for haematological diseases, solid tumours and immune disorders: Current practice in Europe 2009.
In the EU, Mozobil would be indicated in combination with granulocyte-colony stimulating factor to enhance mobilization of hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation
in patients with lymphoma and multiple myeloma whose cells mobilze poorly.
Session: Clinical Allogeneic and Autologous Transplantation
- Results: Poster II
Double autologous transplantation
regimens have been used to treat myeloma for the past decade, but their advantage over single transplantation has been unclear until now, Stadtmauer said.
In Europe, Mozobil is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilization of stem cells to the bloodstream for collection and subsequent autologous transplantation
in patients with lymphoma and multiple myeloma whose cells mobilize poorly.
Professor Gerhard Ehninger, founder of Cellex and Chair of the Department of Hematology at the University Hospital commented, "We learned of burixafor at the 2013 American Society of Hematology meeting and were impressed with its efficacy in autologous transplantation
The technique has been shown in Phase I/II clinical trials to reduce the number of cancer cells to below detectable levels, and thus may eliminate the risk of reintroducing cancer to the patient during autologous transplantation
Mozobil is indicated in the United States for use in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation
in patients with non-Hodgkin's lymphoma and multiple myeloma.
Clinical Allogeneic and Autologous Transplantation
- Results: Allogeneic Transplantation Time: Tuesday, December 10, 2013: 7:30 AM-9:00 AM Location: 208-210 (Ernest N.
Discovering this novel, autologous transplantation
method, where there is no rejection.