The Phase III study is designed to evaluate the safety and efficacy of clobazam in the reduction of atonic seizures
at three dose levels in children and adults (ages 2-60 years) with LGS.
(Drop Attacks) are epileptic events in which the individual loses body tone and consciousness acutely causing the body to drop and fall which can result in severe bodily injury.
This series of articles will discuss several children and adolescents who were initially thought not to be candidates for surgery--including children with extensive neonatal strokes, infants, children with neurocutaneous disorders such as tuberous sclerosis and neurofibromatosis, children with disabling atonic seizures
and developmental delays, and those with extensive trauma.
On the other hand, the most characteristic manifestation of LGS is a large variety of seizures, such as atonic seizures
(sudden loss of muscle tone and consciousness, causing abrupt falls), and atypical absence (starting spells), and myoclonic (sudden muscle jerks).
Other seizures may present with brief jerks of arms and legs, known as myoclonic seizures, or a sudden loss of body tone, known as atonic seizures
or drop attacks.
Four months later, she was having many a day, every day--drop attacks and atonic seizures
The one type of seizure that this surgery helps eliminate is atonic seizures
, also called "drop attacks".