Antimalarial synergy of cysteine and aspartic protease
is a privately held biopharmaceutical company focused on discovering and developing therapeutics that target aspartic proteases
, a group of enzymes central to a variety of human diseases, including Alzheimer's disease.
Identification of a novel aspartic protease
(Asp 2) as R-secretase.
We compared phenotypic markers of pathogenesis, including adherence, biofilm formation, and protein secretion (secretory aspartic protease
[SAP] and phospholipase).
One of these proteases (Histidine Aspartic Protease
, HAP) is homologous to three other aspartic proteases
involved in hemoglobin metabolism but has a histidine in place of one of the two aspartic acids involved in catalysis.
Renin, an aspartic protease
, is rate limiting in the generation of angiotensin (Ang) II, which is a key regulator in the maintenance of salt and water balance by regulating aldosterone secretion and blood pressure (1).
The company has two fundamental technology platforms: (i) aspartic protease
inhibitors, including beta-secretase inhibitors for Alzheimer's disease; and (ii) nicotinic acetylcholine receptor (nAChR) agonists and antagonists for the treatment of angiogenesis mediated diseases and cognitive disorders.