The new study, which analysed pooled data from nine clinical trials involving 31,920 women, looked at the effect on death rates of taking aromatase inhibitors
for five years.
More recently, patients who are postmenopausal also have been offered the option of taking an aromatase inhibitor
(AI) as an alternative to tamoxifen or in sequence after tamoxifen," said Dr.
are used in the treatment of post-menopausal women with receptor-positive breast malignancies in both metastatic and adjuvant settings.
Additionally, for women who have breast cancer and high cholesterol, taking statins may delay or prevent resistance to endocrine therapies such as tamoxifen or aromatase inhibitors
A randomized, placebo-controlled Phase 2 study of entinostat in combination with aromatase inhibitors
in breast cancer (ENCORE 301) demonstrated an improvement in both progression-free survival and overall survival, providing the basis for the evaluation of entinostat in pivotal Phase 3 testing in metastatic breast cancer.
But I never addressed the joint and muscle pain that often accompanies the use of aromatase inhibitors
Red versus white wine as a nutritional aromatase inhibitor
in premenopausal women.
Such reductions were subsequently confirmed in trials testing the other two potent aromatase inhibitors
, letrozole and exemestane.
The 156 women in the prospective cohort had hormone-positive breast cancer and had initiated aromatase inhibitors
from January 2006 to June 2009.
Women who took aromatase inhibitors
were 26% more likely to have heart disease and 47% more likely to suffer a fracture than those on tamoxifen, regardless of how long they took the medicine, an analysis of seven studies used to win approval of the drugs found.
Effect of denosumab on bone mineral density in women receiving adjuvant aromatase inhibitors
for non-metastatic breast cancer: subgroup analyses of a phase 3 study.
If you are not tolerating the drug which can produce nausea, indigestion and hot flushes as well as a long list of other side effects then you may be advised to switch to a class of drugs called aromatase inhibitors
which reduce the amount of oestrogen you produce from other tissues in your body following the menopause.
The three drugs - known as aromatase inhibitors
- can dramatically reduce the recurrence of the disease among post-menopausal women with early breast cancer.
The National Institute for Health and Clinical Excellence (Nice) will today back the use of aromatase inhibitors
for women at any stage of breast cancer.
Today the National Institute for Health and Clinical Excellence (NICE) published a positive Final Appraisal Document (FAD) on the class of breast cancer drugs known as aromatase inhibitors
(AIs) post surgery.