Then 200 collected samples were divided by randomized double blind control trial for 50 patients in 4 groups as follows: 50 patients treated with placebo as a control group, 50 patients treated with Mebendazole 500mg as an experimental 1 st group, 50 patients treated with Thai Traditional Herbal Formula (TTHF) as an experimental 2nd group and 50 patients treated with Areca catechu Lin.
The primary outcome of the study was to compare the efficacy by the % reduction of EPG in each group with treated with Mebendazole, Areca catechu and TTHF medicine.
It showed that there were differences among % reduction of EPG among all 200 patients of sample group treated with Mebendazole (500 mg), TTHF (500 mg) and Areca catechu L.
The collected samples were divided for 50 patients in each group for 4 groups as follows: Placebo control group, treated with Mebendazole experimental group, treated with Thai Traditional Herbal Formula (TTHF) experimental group and treated with Areca catechu Lin.
The efficacy and side effects were compared with the % reduction of EPG in each group with treated with Mebendazole, Areca catechu and TTHF medicine.
Commonly, betel leaf (from the vine Piper betle L), areca nut (the fruit of Areca catechu L), lime (from seashells), gambir (a preparation from the leaves and twigs of the shrub Uncaria gambir), and shredded tobacco are included.
The leaves and stems of Areca catechu were collected in December 2009 from Gazipur district, Bangladesh.
The results obtained from the present study indicate that the methanol extract of the leaves and stems of Areca catechu lowered serum glucose levels dose-dependently and significantly when compared to control (group-I) at all the doses examined.