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situated at an apex

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The apical ectodermal ridge (AER) is one of the main signaling centers during limb development.
SHH is also responsible for the expression of a gene encoding 'Gremlin' which functions as an apical ectodermal ridge maintenance factor8-10.
In the chick embryo, at 96 hours (day 4) of development the apical ectodermal ridge reaches a maximum thickness and height after which it regresses11.
Since phenytoin can disturb the endogenous metabolic processes, it can also have an adverse effect on the embryological development of the apical ectodermal ridge which may be its primary site of teratogenic action.
The apical ectodermal ridge (AER) was recognized under oil immersion lens (100 X objective) fitted with the linear micrometer in the eyepiece.