Tinidazole, an antiprotozoal agent
that has been used in other countries for more than 25 years, also received Food and Drug Administration approval for treating giardiasis, intestinal amebiasis, and amebic liver abscess.
All three metabolites possessed toxicity on mammalian cells, which might limit their use as antiprotozoal agents
Moreover, the choice of antiprotozoal agents
is influenced by factors other than effectiveness, such as drug availability and cost, which differ from country to country.
The potent leishmanicidal activities of certain chemically defined molecules isolated from natural sources have become increasingly important in the search for new antiprotozoal agents
at a time when there is an urgent need for a new group of innovative medicines.
Since the GPI anchor is a protein related to several diseases including BSE and hypophosphatasia, this achievement is expected to elucidate the mechanisms of developing those diseases, promoting the development of various drugs including antfungal, antimalarial and antiprotozoal agents
Among the foremost international journals in antimicrobial research, JAC is published monthly by Oxford University Press and features original articles on the laboratory aspects and clinical use of antimicrobials including antibacterial, antiviral, antifungal, and antiprotozoal agents