On behalf of the subcommittee on lupus anticoagulant/ antiphospholipid antibody
of the scientific and standardization of the ISTH.
Neurometabolite markers of cerebral injury in the antiphospholipid antibody
syndrome of systemic lupus erythematosus.
Most patients with these pregnancy complications had one or more risk factors: a specific antiphospholipid antibody
in the blood, a history of hypertension, and/or a low platelet count.
The routine use of rituximab cannot be recommended as the single series published to date interestingly reported no reduction in antiphospholipid antibody
titer and only improvement in some but not all non-criteria manifestations of APS.
Kawakami T, Yamazaki M, Mizoguchi M, Soma High titer of serum antiphospholipid antibody
levels in adult Henoch-Schonlein purpura and cutaneous leukocytoclastic angiitis.
On the other hand, trials of women with antiphospholipid antibody
syndrome have shown that pregnancy outcomes are improved with the use of aspirin plus heparin.
syndrome is a heterogeneous syndrome, both clinically and in the laboratory.
7 Elevation PC: Protein C deficiency; PS: Protein S deficiency; FVL: Factor V Leiden G1691A mutation; MTHFR: 5,10-Methylenetetrahydrofolate reductase C677T mutation; PT 20210: Prothrombin G2021 OA mutation; FVIII: Elevated factor Vill levels; APA: Antiphospholipid antibody
(anlicardiolipin antibody lgG, IgM and lupus antico-agulant ) Table 3.
Predictive value of persistent versus transient antiphospholipid antibody
subtypes for the risk of thrombotic events in paediatric patients with systemic lupus erythematosus.
Laboratory testing used for diagnosing APS includes coagulation assays for the detection of lupus anticoagulant (LA) and enzyme-linked immunosorbent assay (ELISA) for antiphospholipid antibody
Presence of antiphospholipid antibody
(aPL) alone, in the absence of typical clinical complications, does not indicate a diagnosis of APS; long-term asymptomatic aPL-positive patients exist.
Renal Transplantation in a Patient with Catastrophic Antiphospholipid Antibody
Syndrome (CAPS)," Dr.
We concluded there are few controlled clinical trials that have included a heterogeneous group of APS patients who exhibit many different forms of the disease and antiphospholipid antibody