17] Studies on the pattern of antimycobacterial
drug susceptibility exists but this pattern may change with time and with particular geographical area.
17 One of the reasons of not getting antimycobacterials
from the studied population could be the notion of TB as a taboo in Pakistan.
The high level of HIV-related comorbidity is a reflection of continued late presentation of HIV patients, in addition to the compounding problems of TB-immune reconstitution inflammatory syndrome (TB-IRIS), (7) shared drug toxicities between antiretrovirals and antimycobacterials
, and malabsorption of drugs in wasted, cachexic patients.
Kiraz, Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials
6) Drugs consisted of nine antimalarials, to include chloroquine, sulfadoxine-pyrimethamine, mefloquine, amodiaquine, artemether, artesunate, dihydroartemisinin and two artemisinin-based combination therapies (artemether-lumefantrine and artesunate-amodiaquine); two antimycobacterials
, to include isoniazid and rifampicin; and two antibiotics, to include ciprofloxacin and erythromycin.
A quick look at the way nature, especially plants, are tackling the issue of infection will provide a deeper understanding of the methodology, which needs to be adopted for the design and development of novel highly effective antiinfectious agents in general, and antimycobacterials
rifabutin, rifampin, rifapentine