Antibody responses to antigenic determinants
of influenza virus hemagglutinin.
The RAYS ratios before and after denaturation and the overall distinction between linear and conformational antigenic determinants
of the SARS-CoV N protein are shown in Fig.
Antibodies with specific recognition for specific antigenic determinants
could now be prepared.
This property is especially critical during human pandemics that are characterized by novel antigenic determinants
The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants
unique to either allelic protein product.
While immunologic tests have almost unlimited throughput, the high specificity of these assays may result in failure to identify etiologic agents with different antigenic determinants
To compare with IAPP immunoreactivity measured by another assay detecting different antigenic determinants
, the same samples were assayed by the solid amylin enzyme immunoassay (Amylin Pharmaceuticals Inc) without extraction (4).
The epitopes recognized by certain neutralizing antibodies have been mapped to conformational antigenic determinants
To explain the low sensitivity, it must be considered that anti-CCP antibodies are a heterogeneous group of antibodies directed against different epitopes on the citrulline molecule, that each patient's serum contains different subsets of antibodies, and that the synthetic peptide used in this assay represents a relatively small set of antigenic determinants
that do not entirely encompasses the antigenic determinants
present on the as yet unknown antigenic molecule in the joint (14).