To determine how PRN exposure might adversely affect cell-mediated immunity, we designed the initial experiments of this study to address its potential impact both indirectly (on in vitro antigen presentation to CTLs) and directly (on CTL lytic function).
These results clearly indicate that the class I MHC antigen presentation pathway after PRN exposure, under these conditions, remains intact and fully functional.
We approached this problem with the understanding that impaired cell-mediated immunity can result from the inhibition in antigen presentation to CD[8.
The indirect consequences of these agents on antigen presentation can adversely affect the proliferation, differentiation, and effector functions of T lymphocytes--including cell signaling mechanisms, cytokine secretion, developmental maturation, and target cell lysis by CD[8.
The discovery of the CD1 lipid antigen presentation
system was made by Dr.
The Company's peptide or nucleic acid-based immunotherapeutics, comprise one or multiple naturally processed epitopes (NPEs) designed to comprehensively stimulate a patient's killer T-cells, helper T-cells and to restore or further augment antigen presentation
using proprietary nucleic acid-based expression systems.
By combining ILIT with another proprietary technology, Modular Antigen Transporter (MAT), ImVisioN leverages the potential of ILIT for the development of drugs that use allergens safely for specific and highly effective antigen presentation
Adjuvants provide improved immunity to disease antigens by converting soluble protein antigens into particulates and/or by incorporating microbial constituents, which are able to improve antigen presentation
and activation of signaling receptors associated with both the innate and adaptive immune response.
APX005M is an immuno-activating monoclonal antibody targeting CD40, a receptor that plays a central role in the regulation of antigen presentation
functions and tumor-specific T cell response.
By applying another proprietary technology, Modular Antigen Transporter (MAT), ImVisioN leverages the potential of ILIT to develop drugs that use allergens safely for specific and highly effective antigen presentation
Such signal integration is key to refine the antigen presentation
and results in a straightforward immune response.
Adxs-LmddA159 is an attenuated live Listeria, which can deliver the fusion protein LLO-p53 into the cells of the immune system for antigen presentation
The molecule is designed to target dendritic cells, which play a significant role in antigen presentation
and initiation of an immune response.
Inhibition of cathepsin S may reduce antigen presentation
within certain antigen presenting cells and may therefore have a beneficial effect in the treatment of psoriasis.
This new immunization concept is based on an improved antigen presentation
within the immune system.