Valproic acid, in particular, stands out among older antiepileptics
for elevating risk of congenital malformations.
In contrast, the rate of suicide events for patients with depression alone was significantly higher in those who were taking antiepileptics
than in those who were not (177/100,000 person-years vs.
31, plans to discuss the data at an advisory committee meeting and will work with manufacturers of marketed antiepileptic
drugs to include the new information on product labels, the alert said.
Depakote and Depakene), a leading antiepileptic
drug currently approved for use in the treatment of epilepsy, migraine prophylaxis and bipolar disease, in preclinical studies completed to date, this stereoisomer of valnoctamide has not been associated with the safety concerns (i.
Reversed-phase HPLC (RP-HPLC) has been used to monitor antiepileptics
Amneal's newest first-to-market product is an AB-rated, therapeutically equivalent alternative to the antiepileptic
Felbatol[R] (a registered trademark of Meda Pharmaceuticals Inc.
Meador, principal investigator in the Neurodevelopmental Effects of Antiepileptics
Drugs (NEAD) study.
Robinson and colleagues found that nearly 80% of patients who took a combination of antiepileptics
and antidepressant medications had a greater than 50% visual analogue scale (VAS) improvement, a statistically significant finding.
Patients often do not need to remain on antiepileptics
for life and a long-term goal is to be able to withdraw drug therapy.
Not enough evidence could be gleaned from the reviewed studies to determine whether patients taking antiepileptic
drugs are also at risk for completed suicides, the FDA concluded.
LOS ANGELES -- Adjunctive therapy with lamotrigine significantly reduced the number of primary generalized tonic-clonic seizures in children and adolescents in whom such seizures are inadequately controlled with other antiepileptic
drugs alone, judging from findings reported by Dr.
Market dynamics: Sales growth statistics for BPD-approved agents versus non-BPD-approved agents; sales and prescriptions of antipsychotics and antiepileptics
in the United States.
However, there are far fewer data on the reproductive risks of newer antiepileptics
such as lamotrigine and gabapentin.
And in some cases, managing physicians discontinue the therapy, either because they are uncomfortable with managing antiepileptics
or because they rediagnose the patients with another disorder.
There are not much data yet on the safety of the new generation antiepileptics
, such as lamotrigine (Lamictal) and gabapentin (Neurontin), when used during pregnancy.