anticonvulsant

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This sub-analysis evaluates the efficacy and safety of perampanel by baseline antiepileptic drugs in subjects 12 years of age or older with uncontrolled PGTCS and taking 1-3 concomitant antiepileptic drugs.
Food and Drug Administration (FDA) has accepted for review the company's supplemental New Drug Application (sNDA) for its in-house developed antiepileptic drug Fycompa (generic name: perampanel) for the treatment of primary generalized tonic-clonic seizures (PGTC), a severe form of seizures, in patients 12 years or older.
8% at 24 months and "was higher in a subgroup of patients who had no change in antiepileptic drugs during the study," wrote Dr.
Mothers who had epilepsy provided data about the use of antiepileptic drugs during pregnancy and breastfeeding.
It also has minimal effects on the disposition of other antiepileptic drugs and can be used synergistically, making it an ideal adjuvant medication for patients with refractory epilepsy.
It outlines 34 antiepileptic drugs in alphabetical order, with information on general therapeutics, pharmacokinetics, the interaction profile, adverse effects, dosing and use, special populations, and the overall place of the drug in epilepsy treatment.
Fifty-three men treated with antiepileptic drugs for at least two years prior to enrollment in the Anti-Epileptic Drug and Osteoporosis Prevention Trial (ADOPT) were randomized to receive risedronate (a drug that helps prevent fractures) or a placebo for 12 weeks.
Since women in the study were taking antiepileptic drugs throughout pregnancy, it is unclear whether the effects on IQ are related to the timing or duration of prenatal valproate exposure, so "exposure to valproate at any time during pregnancy should be considered to have the potential to result in decreased IQ in children," the advisory says.
The cases were defined as women with active epilepsy on or off antiepileptic drugs who were intending to get pregnant.
Washington, June 22 (ANI): A discovery made by University of California, Riverside researchers in the lab could help drug manufacturers develop new antiepileptic drugs and explore novel strategies for treating seizures associated with epilepsy.
The experts said: "Although most antiepileptic drugs taken during pregnancy significantly increase the risk for one or more specific fetal malformations, the occurrence of these malformations is nevertheless rare.
Other areas explored include the application of nanotechnology in pharmacotherapy, therapeutic monitoring of antiepileptic drugs, a mathematical modeling approach for testing drug effects on the hepatitis C virus, and recent developments in drug monitoring with high performance liquid chromatography.
Unfortunately, not only are current treatment options limited, but most of the antiepileptic drugs have severe adverse effects.
A CAMPAIGN to ensure antiepileptic drugs are exempted from Government plans to use cheaper versions is gathering local support.
Our message is make antiepileptic drugs permanently exempt from generic substitution.