The use of probiotics in the prevention and treatment of antibiotic-associated diarrhea
with special interest in Clostridium difficile-associated diarrhea.
Probiotics in the prevention of antibiotic-associated diarrhea
in children: a meta-analysis of randomized controlled trials.
Probiotics for prevention of antibiotic-associated diarrhea
Two recent systematic reviews have shown favorable support for using probiotics in the prevention and treatment of antibiotic-associated diarrhea
(Hempel et al.
Practice Implications: While antibiotic-associated diarrhea
(AAD) is a risk factor across many age groups, diarrhea secondary to C.
These scientific studies strengthen the positive influence of probiotics in maintaining and improving health and quality of life including preventive and therapeutic application possibilities on infectious or antibiotic-associated diarrhea
, influence on the intestinal flora, and the reduction of pathogenic mircoorganisms, metabolites, and enzymes as well as immunostimulating properties and the reduction of allergenic and atopic complaints.
This is considerably higher than the 10 to 20% positivity rate per submitted stool sample among patients with antibiotic-associated diarrhea
in most other studies.
These good bacteria have also been proven to shorten the course of infectious diarrhea in children, lessen antibiotic-associated diarrhea
, and may help "maintain remission of ulcerative colitis and prevent a relapse of Crohn's disease," according to the Harvard Women's Health Watch newsletter.
Similar frequency of detection of Clostridium perfringens enterotoxin and Clostridium difficile toxins in patients with antibiotic-associated diarrhea
Dorothy Ogden (not her real name) learned the hard way that antibiotic-associated diarrhea
can persist in some people long after they've beaten their original infection and stopped taking antibiotics.
Twenty-percent of all antibiotic-associated diarrhea
and most cases of pseudomembranous colitis are attributable to this organism (Walker et al.
The need for new infectious disease therapeutic approaches is great, and Kemin Pharma's early focus on gastrointestinal disorders is compelling, given the worldwide population of individuals suffering from such diseases as acute diarrhea, antibiotic-associated diarrhea
, Inflammatory Bowel Disease and Irritable Bowel Syndrome.
(AAD) is caused when antibiotic use alters the microbial balance.
difficile) can cause antibiotic-associated diarrhea
, whereas non-toxigenic C.
Take a recent study for example published May 2012 in the Journal of American Medical Association, a review of 63 randomized controlled trials showing that out of 11,811 people, those who were on probiotics had an associated reduction in risk of antibiotic-associated diarrhea