10 /PRNewswire/ -- Procter & Gamble Pharmaceuticals announced today it has submitted a new drug application (NDA) with the US Food & Drug Administration seeking approval to market its investigational antiarrhythmic drug
, azimilide, in the United States.
This agent acts by blocking both rapid and slow potassium channels in myocardium, and is chemically distinct from other class III antiarrhythmic drugs
like sotalol, amiodarone, and dofetilide.
For those patients who had reached six months, 7/7 (100%) patients experienced normal sinus rhythm without antiarrhythmic drugs
Section Three describes several novel pharmacological targets for antiarrhythmic drugs
, including both ion channel and non-ion channel targets.
Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that more than 70 percent of surveyed cardiologists and 60 percent of surveyed managed care organizations' (MCOs) pharmacy directors consider amiodarone (Sanofi-Aventis's Cordarone, generics) to be the most effective antiarrhythmic drug
for maintaining normal sinus rhythm (NSR) in patients with atrial fibrillation.
Physicians tend to think of ablation and antiarrhythmic drug
therapy as separate treatments, but "there can be synergies between the two," Dr.
Or alternatively, the current antiarrhythmic drugs
and warfarin therapy that we use may cause enough harm to offset the benefits of being in sinus rhythm.
Key Market Drivers Include the Launch and Rapid Uptake of New Oral Anticoagulants and Atrial-Selective Antiarrhythmic Drugs
, According to Findings from Decision Resources
Left atrial modification by surgery will block the propagation of the multiple wavelets and antiarrhythmic drugs
(AADs) may affect both of these processes.
Monitor all [patients on] antiarrhythmic drugs
more frequently during pregnancy than you otherwise would," he said.
Fogoros presents an updated guide to antiarrhythmic drugs
for nonexperts--practitioners, trainees, and students--who are frequently called upon to make decisions regarding actual patients with cardiac arrhythmias.
These results add to a growing body of literature demonstrating that catheter ablation improves quality of life more than antiarrhythmic drugs
in appropriately selected patients.
The book also has excellent in-depth coverage of other approaches in pain therapy, such as gabapentin, gabapentinoids, sodium channel blockers (including antiepileptic drugs such as phenytoin, carbamazepine, and lamotrigine and antiarrhythmic drugs
such as mexiletene), potassium channel blockers, and calcium channel antagonists.
One group reported that intermittent tachyarrhythmias have "a deleterious effect on the fetus with a significant risk of death pre- or postnatally" and called for broader use of maternal antiarrhythmic drugs
were discontinued in five patients, and none had to be increased in dosage or newly prescribed.