NASDAQ-NMS: AGPH) announced that clinical investigators reported interim results of Phase I safety and dosing studies of its anti-tumor
agent AG337 in presentations yesterday at the annual meeting of the American Association for Cancer Research in San Francisco.
Our research suggests stem cells have an inherent ability to contribute to the microenvironment of tumors independent of histology or location, and can be manipulated to express anti-tumor
genes," said Michael Andreeff, M.
A structurally unrelated anti-tumor
agent designated AG-337 -- also designed to inactivate TS -- is the subject of a Phase I clinical study on cancer patients initiated two months ago in England.
In the study the scientists found that during the heat activated liposome administration the time at which the heat was applied could be used to control the amount of drug delivered to different areas of a tumor and its anti-tumor
5-FU must be metabolized in the cells to produce another substance, which in turn produces the desired anti-tumor
The objectives of this study are to determine safety, tolerability and a recommended Phase 2 dose, to define the pharmacokinetic profile and to assess the preliminary anti-tumor
activity of ARQ 197.
The objectives of this study were to determine the maximum tolerated dose, dose-limiting toxicity, safety, tolerability and preliminary anti-tumor
activity of the combination of ARQ 501 and docetaxel.
In these studies AG-331 demonstrated significant anti-tumor
activity in vitro, killing a range of cultured human and murine tumor cells, including cells known to possess one of the most common mechanisms of drug resistance.
The protocol is based on published data showing that administration of M-Vax alone can induce clinically meaningful anti-tumor
responses in patients with stage IV melanoma.
The Phase 1 study is also designed to observe anti-tumor
effects of TOCOSOL Camptothecin as well as to characterize the pharmacokinetics of the drug.
By inhibiting these select DPPs, talabostat has been shown in preclinical models to cause an increase in IL-1 beta, a cytokine believed to play an important role in the positive regulation of immune responses, which in turn stimulates the production of a variety of cytokines and chemokines that promote the anti-tumor
activity of neutrophils, macrophages and T lymphocytes.
This drug candidate is distinguished by its anti-tumor
and anti-angiogenesis combination mechanism, 100% oral bioavailability and potential to treat resistant tumors.
Nasdaq: ARQL) today announced data from two Phase 1b combination therapy trials, one with ARQ 501 and docetaxel and one with ARQ 501 and gemcitabine, that support previously announced findings demonstrating clinical tolerability, favorable pharmacokinetics and promising signs of anti-tumor
activity in cancer patients with a range of advanced solid tumors who had failed prior treatments with chemotherapy.
Advaxis has shown that various fragments of Her-2 not previously known to have activity, when combined with its proprietary Listeria based vectors, are showing strong anti-tumor
activity in animals.
OTCBB:EGEI), developers of a revolutionary high-performance genetic analysis technology, announced today that its analyzer was used in large-scale screening for genotyping related to anti-tumor
medication and was found to be a highly efficient tool in a clinical laboratory setting.