3) Many cases result from partial androgen deficiency
in the aging male, because testosterone levels decline an estimated 1% to 2% per year in adult men.
Guidelines issued by the task force members advise that physicians instead offer testosterone therapy on an individual basis to older men with consistently low testosterone levels on more than one occasion and clinically significant symptoms of androgen deficiency
Signs and symptoms that are suggestive of androgen deficiency
include incomplete sexual development, reduced libido, decreased spontaneous erections, gynecomastia or breast tenderness, loss of axillary or pubic hair, reduced shaving, testes size less than 5 mL, low bone-mineral density, reduced muscle bulk, hot flashes, and infertility.
is characterized by a decrease in prostate volume and serum PSA level.
13) In women with androgen deficiency
, DHEA supplementation has been reported to increase alertness, stamina, and sexual interest.
In addition, an Australian study examined the influence of testosterone replacement on fat and muscle in 60 nonobese men aged 55 years and older who had symptoms of androgen deficiency
The theory behind androgen replacement is that androgen deficiency
causes clinical symptoms such as dysphoria, fatigue, and low sex drive.
Testosterone therapy in men with androgen deficiency
syndromes: Endocrine Society Clinical Practice Guideline.
PURPOSE OF REVIEW: The burden of androgen deficiency
in men with diabetes and the metabolic syndrome has become increasingly apparent in population-based studies.
MUNICH -- Hormone therapies that produced androgen deficiency
in men were associated with significant prolongation of the QT interval in three different prostate-cancer studies.
resulted in a QT interval increase that was comparable to the effect of a low dose of sotalol or dofetilide.
Ten studies used the International Index of Erectile Dysfunction (IIEF) as the main scoring system for baseline and follow-up assessment of treatment response, while the other 4 studies used the Androgen Deficiency
in Aging Male (ADAM) questionnaire,[sup.
The androgen deficiency
problem is not now recognized by practicing physicians, who are increasingly prescribing opioids or seeing patients on these medications.
The Androgen Deficiency
in Aging Males (ADAM) instrument (Appendix 1) is most widely accepted.
4) A publication using the Androgen deficiency
in aging questionnaire (ADAM) in a young population suggested that symptoms were associated with levels at or below 400 ng/dl.