HAART and progression to high-grade anal intraepithelial neoplasia
in men who have sex with men and are infected with HIV.
Anal intraepithelial neoplasia
in a multisite study of HIV-infected and high-risk HIV-uninfected women.
Anal intraepithelial neoplasia
in women with genital intraepithelial neoplasia.
The role of routine anal Pap smear screening is controversial in part because a clear link between anal intraepithelial neoplasia
(AIN) and anal cancer has long been assumed, but never demonstrated in prospective trials.
GARDASIL is not intended to be used for treatment of active external genital lesions; cervical, vulvar, vaginal and anal cancers; cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, or anal intraepithelial neoplasia
Screening for anal cell abnormalities" defines the basic steps of screening for anal cell abnormalities and testing for and treating anal intraepithelial neoplasia
Given the current recommendation of utilizing the HPV vaccine for the prevention of HPV-associated anal intraepithelial neoplasia
in certain groups, such as MSM (13,14,15), and in this time in which no national guidelines exist regarding recommendations for routine anal cancer screening (16), it is important to document the burden of anal cancer in both men and women in this Hispanic population.
The quadrivalent HPV vaccine reduced the rate of persistent anal infection with HPV types 6, 11, 16, and 18, as well as the anal intraepithelial neoplasia
associated with these viral types, in an industry-sponsored study of homosexual men.
3,4) The HPV types implicated in anal intraepithelial neoplasia
are similar to those described for the cervix, and it is not infrequent to observe infection by multiple types.
Human papillomavirus (HPV) can cause anal as well as genital warts, and some strains, especially HPV 16 and 18, can cause anal cancer and its precursor, high-grade anal intraepithelial neoplasia
1) Older age, receptive anal intercourse, and infection with anal human papillomavirus (HPV) raised the risk of low-grade anal intraepithelial neoplasia
(AIN), the less threatening type of abnormal anal cell growth studied.
Data are limited on the natural history of anal intraepithelial neoplasia
, however, and the CDC declined to recommend screening until more information becomes available.
The quadrivalent HPV vaccine lowers rates of external genital lesions and anal intraepithelial neoplasia
(AIN), an anal cancer precursor, in MSM.
The new recommendation takes into account recent evidence demonstrating that the vaccine prevents anal intraepithelial neoplasia
(AIN) in males, in addition to genital warts.
For these recommendations, ACIP considered information on vaccine efficacy (including data available since October 2009, on prevention of grade 2 or 3 anal intraepithelial neoplasia
[AIN2/3], a precursor of anal cancer), vaccine safety, estimates of disease and cancer resulting from HPV, cost-effectiveness, and programmatic considerations.