When paired with strong, porous carbon in a membrane, the lab-made amyloids
successfully filtered over 99 percent of toxic materials out of solutions that mimicked severely polluted waters, the scientists report.
To find out if amyloids
can behave like enzymes too, Korendovych and his team designed seven simple peptides that were made from seven amino acids.
Our biosensor test uses a new molecular recognition tool that works like a lock that only fits one key; it picks out the ball-shaped amyloid
clusters without detecting the individual amyloids
(A[sz]) peptides are generated as cleavage products 39 to 43 amino acids in length from the membrane protein, Amyloid
Precursor Protein (APP) by two proteases, ?
The results are the first to suggest that toxic desmin amyloids
can form in response to stress placed on the heart.
We report 2 cases of laryngeal amyloidosis in which dense plasma cell infiltrates were found in the vicinity of the amyloid
deposits; in view of this finding, we suspected a hematologic disease--plasmacytoma in particular.
Amyloidosis in humans was first recognized in the mid-19th century when Rudolf Virchow coined the term amyloid
(for starch or cellulose) to describe abnormal extracellular material seen in the liver at autopsy.
These findings are significant because it is the first time a combination of specific chemicals has successfully destroyed diverse forms of amyloids
at the same time," Nature magazine quoted Dr Martin Duennwald of BBRI, who co-led the study with Dr.
Many researchers hold that plaques consisting of an amyloid
known as beta-amyloid
kill brain cells and thereby cause Alzheimer's disease.
This immunization, they found, generated antibodies that prevented the accumulation of beta-amyloid
within the mouse brain and even cleared existing amyloid
deposits, known as plaques.
plaques are lesions that form between brain neurons as protein fragments (beta-amyloids
) are snipped off.
In a related development had underscores the importance of amyloids
, investigators report in the July 18 NATURE that mice genetically engineered to over-produce an amyloid
precursor protein (of which beta amyloid
is a fragment) develop plaques similar to those seen in Alzheimer's.
Since completing the reported study, she and her co-workers have made genetic probes that distinguish between the two forms of amyloid
(with and without the built-in inhibitor), and have gotten what Neve calls "exciting" preliminary results on the distribution of different amyloids
hypothesis isn't dead, but it seems to be limping a bit in the race for an Alzheimer's cure.
Precursor Protein, APP, is predominantly processed by a-Secretase, producing a 83-amino acid C-terminal fragment, C83; while a small amount is processed by b-Secretase, producing a 99-amino acid C-terminal fragment, C99.