Because solubility is the key parameter driving the formulation work on amorphous solid
dispersions, it is very important to have a comprehensive knowledge on dissolution of dosage forms and testing.
8]A (14 mg), was obtained as yellow amorphous solid
and minor constituent with [R.
For amorphous solids
, the activation volume tensor has two independent components.
The term amorphous solid
dispersion (ASD) is often used in the scientific literature to refer to a single-phase solid solution.
Hovione provides several pioneering particle engineering technologies based on amorphous solid
dispersions, crystal design and reduction and control of particle size.
Many interesting and excellent experimental data on yielding and fracture for both crystalline and amorphous solid
polymers have been published (3-6), and some qualitative explanations of plastic deformation have been proposed (7-9).
In contrast, physicists have discovered that an amorphous solid
takes longer to relax than would be expected if the relaxation simply followed an exponential decay.
Volume of mixture was reduced to 7-10 mL by distillation and then excess of distilled water was added to afford light yellow precipitates of 1-(2,4-dihydroxyphenyl)-1-ethanone hydrazone 2 as amorphous solid
which was filtered and washed with distilled water and dried.
The company's portfolio of services now includes crystal design, particle size reduction to the micro- or nano-scale and amorphous solid
Compound 7a was synthesized as white amorphous solid
with melting point of 152-154 o C.
Formulation development - stabilized amorphous solid
dispersions and controlled release dosage forms (spray drying, solvent-based fluid bed processing); lipid formulation; solubilized systems; capsules and tablets; liquid formulation for poorly soluble drugs
Formulation development--stabilized amorphous solid
dispersions; lipid formulation; solubilized systems; capsules and tablets; liquid formulation for poorly soluble drugs
Compound 1 was obtained as an amorphous solid
, which exhibited strong absorption bands in IR spectrum at 3440 (O-H), 3300 (N-H), 1660 (C=O), 1505 and 1480 (Ar.