Some of the members of this class of cuproenzymes include Cu/Zn SOD (antioxidant defense), cytochrome C oxidase (mitochondrial respiration), CP (iron metabolism), tyrosinase (pigmentation), lysyl oxidase (collagen maturation in connective tissue), Hephaestin (intestinal iron efflux), dopamine [[beta]-hydroxylase (catecholamine synthesis), Peptidylglycine [alpha] -amidating monooxygenase (peptide-hormone processing), amine oxidase (removal of hormones), ascorbate oxidase and catalase oxidase (oxidation of primary alcohols to aldehydes) (44).
TYRP1, Tyrosinase-related protein 1 Group 3: Copper amine oxidase 1.
Pea seedlings amine oxidase (PSAO) has been found to have a 100% relative specific activity towards 1,4-diaminobutane, 111% towards 1,5-diaminopentane, 56% towards agmatine and spermidine, 44% towards 1,6-diaminohexane, 30% towards histamine, 8% towards spermine, and no activity towards 1,3-diaminopropane .
The aim of the present study was to extract and purify amine oxidase from pea seedlings, to determine the activity and selectivity of the purified enzyme towards different amine substrates with a Clark-type oxygen sensor, and to examine the possible application of the enzyme as a bioselective element in amine biosensors.
The amine oxidase preparation was stable at -18[degrees]C and there was no detectable loss of activity in 6 months at this temperature.
Studying a bovine amine oxidase, two independent research groups found clues that pyrroloquinoline quinone (PQQ) might be the enzyme's missing sidekick in cows -- and perhaps in humans as well, Klinman says.
Instead, TOPA turned out to be a built-in partner, which the cell fashions (after the amine oxidase is made) by modifying one of the enzyme's component amino acids.
Pea seedlings (Pisum sativum) have been found to contain a substantial amount of amine oxidase (EC 1.
The molecular weight of pea seedlings amine oxidase (PSAO) has been found to be between 150 and 180 kDa [2, 7].
In developing the biosensor, they used the enzymes diamine oxidase, monoamine oxidase and plasma amine oxidase
as the specific biological recognition compounds in a continuous flow system.
Vascular adhesion protein-1 (VAP-1) is also called semicarbazide-sensitive amine oxidase
Executive Vice President of Research and Chief Scientific Officer, presented data concerning the Company's compounds that inhibit SSAO as potential treatments for autoimmune and inflammatory diseases at the 12th Amine Oxidase
and Trace Amines Workshop, in Rotterdam, The Netherlands.
A key scientific target is the realisation of intelligent electronic devices which respond to biomolecules such as formaldehyde, amines, metal ions, saccharides, activities of amine oxidases
, arginase and glutathione-S-transferase.
Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases
, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases.
Chapter 7 Enantioselective synthesis by aldolases, amine oxidases
, transaminases and oxynitrilases