The thiazide-type diuretic used in that study was not only found to provide superior protection against new-onset heart failure, but was also observed to be superior to the alpha blocker
(doxazosin) in protecting against stroke, and to the ACE inhibitor (lisinopril) in protecting against stroke in blacks.
therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5-alpha reductase inhibitor dutasteride.
The most common drug-related AE was retrograde ejaculation (orgasm with reduced semen), an expected treatment effect of selective alpha blockers
, which occurred in 20.
This treatment benefit compares favorably to the mean symptom score improvement typically found after 3 months for currently approved BPH medications such as alpha blockers
(in the 5 point range) and 5 alpha reductase inhibitors (in the 3 point range).
The most common drug-related adverse event (AE) was retrograde ejaculation (orgasm with reduced semen), an expected treatment effect of selective alpha blockers
, which occurred in 28 percent of men treated with RAPAFLO(TM).
Studies of alpha blockers
and 5 alpha reductase inhibitors have shown that these approved drugs are stopped by a large percentage of men who are prescribed them, due to intolerance of the side effects of the drugs such as dizziness, weakness, erectile dysfunction, loss of libido, retrograde ejaculation, gynecomastia, syncope, and many other frequent problems.
The most common drug-related side effect was retrograde ejaculation (orgasm with reduced semen), an expected effect of selective alpha blockers
8 Alpha Blockers
Will Maintain a Respected Position in the Hypertension Market
While the cholesterol management market remains dominated by statins and fixed-dose combination drugs containing statins, the market for drugs to treat hypertension covers a number of classes, such as beta blockers, ACE inhibitors, angiotensin-II receptor antagonists, calcium channel blockers and alpha blockers
The study population represented a truly 'hard core' group of patients who had failed multiple previous therapies including antibiotics, phytotherapy, alpha blockers
, neuromuscular therapies and prostatic massage," said Daniel Shoskes, MD, study principal investigator.
QTc prolongation has been observed with other alpha blockers
Flomax stands out among alpha blockers
thanks to its lower propensity to induce orthostatic hypotension, despite evidence of a high incidence of retrograde ejaculation and higher cost relative to generic agents in this class", said Nathan Calloway, analyst at Decision Resources.
The therapeutic agents considered in the model include the TNF alpha blockers
Enbrel and Remicade along with the IL-1 blocker, Kineret.
Traditional treatment involves anti-inflammatory agents and alpha blockers
, heat, massage and sometimes surgery.
The new Pharmacor report entitled Benign Prostatic Hyperplasia finds that the market to treat the disease is dominated by two drug classes -- alpha blockers
and 5-alpha-reductase inhibitors -- which make up 93% of drug sales in the United States, France, Germany, Italy, Spain, the United Kingdom, and Japan.