These trials confirmed the Company's discovery that, of the three alpha adrenergic
receptors, the alpha 1-a receptor is an appropriate target for BPH.
The Global Glaucoma Therapeutics market can be divided into five segments: Prostaglandins, Beta Blockers, Alpha Adrenergic
Agonists, Carbonic Anhydrase Inhibitors, and Fixed Dose Combinations.
When patients were divided into subgroups due to alpha adrenergic
blocker treatment, Qmax and Qave values were significantly higher in the sitting position and other parameters did not show any statistically significant difference.
The alpha adrenergic
antagonist prazosin has shown promise in multiple case and chart reviews, open-label trials, and placebo-controlled studies.
If this is correct, the standard treatment of using alpha adrenergic
agonists may need to be rethought (14).
There are five classes of medications that are considered first-line agents for treatment of hypertension--diuretics beta blockers, alpha adrenergic
blockers, calcium channel blockers.
Synaptic Pharmaceutical Corporation (Paramus, NJ; 201-261-1331) announced that it has been awarded a United States patent (6,156,518) for the use of the alpha adrenergic
1B and 1D receptors to screen compounds that bind to them.
The market scenario will change after the launch of new disease-modifying therapies such as NGF binders, transient receptor potential vanilloid (TRPV) antagonists, calcium channel blockers, non-peptide neurotoxins, alpha adrenergic
receptors, p38 kinase inhibitors, fatty acid amides hydrolase inhibitors, alpha-2 delta ligands, bradykinin (B2) receptor, N-Methyl-D-aspartate (NMDA) antagonists, sigma 1 agonists and so on.
Phenylephrine is a sympathomimetic agent which acts primarily as an alpha adrenergic
In March of this year Synaptic began to make available non-exclusive licenses to its alpha adrenergic
and benign prostatic hypertrophy patents.
307 (14%) took alpha adrenergic
receptor blockers (-ARs).
Using ACADIA's functional genomics platform as the foundation for discovery efforts and Allergan's disease models and medicinal chemistry, the companies successfully identified and validated the specific alpha adrenergic
gene product that affects intraocular pressure and developed AGN 195795, a gene product specific small molecule drug that selectively activates this gene target.