Reporting online in the journal Neuron on June 25, the researchers show that specialized sensory neurons called nociceptors are not only activated by allergic inflammation
, but also exacerbate the allergic immune response.
In mice, supplementation of the maternal diet with methyl donors was associated with greater airway allergic inflammation
and IgE production in offspring and passed through generations.
These cytokines are able to induce IgE production and to activate eosinophils leading to allergic inflammation
Cardinal events during allergic inflammation
can be classified as activation, organ selective homing, survival and reactivation and effector functions of immune system cells (1).
Lotti and other researchers have hypothesized that an interconnection between genetic and environmental factors may predispose a patient to allergic inflammation
, which may then cascade in a vulnerable individual into a long-lasting diminished capacity for appropriate protective reactivity within the hypo-thalamus-pituitary-adrenal (HPA) axis.
Researchers found that mutations in the filaggrin gene in mice leads to allergic inflammation
, comparable to that seen in human eczema and related allergic diseases.
OBJECTIVE AND DESIGN: Mast cell-mediated allergic inflammation
is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis.
fumigatus conidia and their associated ability to produce proteases, is necessary in the development of allergic inflammation
In some embodiments the altered versions of CXCR3 are used, inter alia, for the direct identification of candidate compounds such as receptor agonists, inverse agonists, partial agonist or antagonist for use in, for example and not limitation, graft rejection; inflammatory skin disease; inflammatory bowel disease; allergic inflammation
, allergic pulmonary inflammation, inflammatory demyelinating neuropathy, CNS inflammation; rheumatoid arthritis, bronchiolitis obliterans syndrome, periodontal disease and neurodegenerative disease.
The majority of employees at the Powertrain plant now suffer from Alveolitus or 'occupational asthma', an allergic inflammation
of the lung caused by prolonged exposure to dust .
Alveolitis is an allergic inflammation
in the inner part of the lungs caused by prolonged exposure to dusts.
The symposium, held in London in November 2004, drew researchers from Britain, North America, and Japan to share knowledge on the roles of the two granulocytes in varied disease settings, such as those occurring an allergic inflammation
and autoimmune disease.
Details of the research are available in an article, entitled "Basophilis play a crucial role in the development of IgE-mediated chronic allergic inflammation
independently of T cells and mast cells," that appeared in the August issue of US scientific magazine Immunity.
A better understanding of immunoglobulin E-mediated, mast cell-dependent allergic inflammation
has resulted in the development of new therapies for allergic respiratory disease.
This reduces allergic inflammation
, prevents asthma exacerbations, and reduces asthma symptoms, according to Genentech.