Key Words: heart failure, left ventricular dysfunction, angiotensin-converting enzyme inhibitors, beta blockers, aldosterone antagonists
, angiotensin-receptor blockers, digoxin
According to the American College of Cardiology/American Heart Association Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult, the addition of aldosterone antagonists
should be considered for patients with recent or current symptoms at rest despite the use of angiotensin-converting enzyme inhibitors, diuretics, beta-blockers, and/or digoxin.
Angiotensin converting enzyme inhibitors used in combination with aldosterone antagonists
decrease the risk of progressive cardiac failure and sudden cardiac death (24).
The important caveat regarding the aldosterone antagonists
is that they should be used only in patients with an estimated glomerular filtration rate greater than 30 mL/min per 1.
This study wasn't designed to determine why the results contradicted the "impressive benefits of aldosterone antagonist
therapy" reported in "pivotal" efficacy trials as well as in a systematic review of randomized clinical trials of the therapy.
2 Percentage of patients who receive the aldosterone antagonist
drug eplerenone for the treatment of Hypertension
Spironolactone HCl is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist
in the class of pharmaceuticals known as potassium-sparing diuretics.
The best multidrug combinations for isolated systolic hypertension include diuretics; ACE inhibitors or angiotensin receptor blockers; dihydropyridine calcium channel blockers; and an aldosterone antagonist
, he said.
Specifically, CRT and ICD use increased by 30 and 27 percent, respectively, and aldosterone antagonist
use increased by 25 percent, all compared to baseline results.
Baseline background treatment included beta-blockers (92%), an ACE inhibitor/angiotensin-receptor blocker (96%), or an aldosterone antagonist
The open-label study of heart failure patients with chronic kidney disease is intended to explore dosing of RLY5016 and an aldosterone antagonist
with the aim of maintaining serum potassium levels in the normal range.
PARIS--The aldosterone antagonist
eplerenone cut cardiovascular events and the need for hospitalization significantly across all risk levels in patients with mild heart failure, according to a subanalysis of the EMPHASIS-HF trial.
The use of eplerenone, an aldosterone antagonist
, also significantly reduced all-cause mortality by 24%, hospitalization from any cause by 23%, and heart failure hospitalization by 42%.
NYSE: MDT), demonstrated that clinics using the process improvement program increased adherence to evidence-based, guideline-recommended care by 82 and 62 percent, respectively, for cardiac resynchronization therapy (CRT) and implantable cardioverter-defibrillator (ICD) use, and 80 percent for aldosterone antagonist
use, all relative to baseline results.
The optional combination would be a thiazide and aldosterone antagonist