Lycera's synthetic RORgamma agonists
bolster the generation of effector immune cells, including Th17 and Tc17 T cells.
These regimens are characterized by the use of relatively low doses of GnRH agonists
starting in the mid-luteal phase of the cycle and usually ending at the time of menses or soon afterward, in combination with high doses of gonadotrophins.
An initial evaluation of assay performance showed that the assays behaved as expected in terms of biological activity of known agonists
and antagonists included as positive control compounds in the screening libraries.
also make a common problem--obesity--worse," Dr.
There are currently no selective Delta agonists
approved by the FDA.
There is no limit to the number of vaccines to which Merck can apply Idera's agonists
within the licensed fields.
The [alpha]-1 agonists
phenylephrine, angiotensin, and metaraminol were relegated to second-tier status for preventing hypotension among obstetric patients after animal studies showed the agents had deleterious effects on uterine blood flow In their place, ephedrine became the vasopressor of choice for treating and preventing hypotension in obstetric settings.
"significantly attenuated all [physical] withdrawal symptoms measured," the investigators assert.
The American Academy of Allergy and Immunology has been concerned that media reports which question the use of beta-2 agonists
to treat asthma have caused great anxiety among asthmatics and the public.
longitudinal patient-level claims data that dipeptidyl peptidase (DPP-IV) inhibitors claim a larger share of newly diagnosed type 2 diabetes patients across all three lines of therapy compared to peroxisome-proliferator activated receptor (PPAR)-gamma agonists
today reported that a new study published in the current online edition of the Proceedings of the National Academy of Sciences (PNAS) shows that Biscayne's growth hormone-releasing hormone (GHRH) agonists
increase the viability and functionality of pancreatic beta islet cells in multiple models of Type 1 diabetes.
The toxic equivalency factor (TEF) approach for analyzing joint effects of dioxin-like chemicals assumes that individual agents are full aryl hydrocarbon receptor (AhR) agonists
with parallel dose--response curves; but many mixtures also include partial agonists
We hypothesized that among the different types of agonists
tested, the performance of catecholamines on alpha ARs will be higher than that of the synthetic compounds of the imidazoline and guanidine chemical classes because most of the catecholamines tested were endogenous or derivatives of the endogenous neurotransmitters in the brain.
Patients with Parkinson's disease who received the drugs pergolide or cabergoline had profoundly higher rates of clinically significant valvular heart disease than did those taking other dopamine agonists
, in two European studies.
The Competitive Intelligence Report Peroxisome Proliferator-Activated Receptor (PPAR) Agonists
as of November 2008 provides a competitor analysis in the development pipeline of novel PPAR alpha, gamma and delta agonists
for treatment of dyslipidemia or type 2 diabetes or obesity.